The hypothesis of this study based on OPG is the decoy receptor of sRANKL which bind with its receptor RANK and activate NF-κB. This pathway may involve in the pathogenesis of IBD and any interference with pathway may affect the progress of the disease. The role of RANK/RANKL inhibition as an immunomodulatory.  While TFF3 is a good marker indicating healing of mucosa   and a state of remission.