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Steroid/Antiviral for the treatment of Bell’s
palsy: Double blind randomized clinical trial

ملخص البحث
Abstract. Background: A large number of patients with Bell’s palsy fail to recover facial function completely after steroid therapy. Only a few small trials have been conducted to test whether outcomes can be improved by the addition of antiviral therapy. Objective: To evaluate the efficacy of treatment with steroid alone versus steroid + antiviral in a group of patients with moderately severe to severe acute Bell’s palsy. Methods: Fifty eligible patients out of a total of 65 with acute onset Bell’s palsy were randomized to receive the two treatments. Evaluation was performed before starting treatment, after 2 weeks of treatment and 3 months after onset, using the House and Brackmann facial nerve grading system (HB) and the Sunnybrook grading system. This study was registered with ClinicalTrials.gov, number NCT02328079. Results: Both treatments had comparable demographics and clinical scores at baseline. There was greater improvement in the mean HB and Sunnybrook scores of the steroid + antiviral group in comparison to steroid group at 3 months. At the end of the 3rd month, 17 patients (68%) had good recovery and 8 patients (32%) had poor recovery in the steroid group compared with 23 patients (92%) and 2 (8%) respectively in the steroid and antiviral group (p = 0.034). Conclusion: The combination of steroid and antiviral treatment increases the possibility of recovery in moderately severe to complete acute Bell’s palsy.
مؤلف البحث
Eman Mohamed Khedr,∗, Reda Badry, Anwer Mohamed Ali, Noha Abo El-Fetoh, Dina Hatem
El-Hammady, Abeer Mohamed Ghandour and Ahmed Abdel-Haleem
مجلة البحث
Restorative Neurology and Neuroscience
صفحات البحث
897–905
الناشر
IOS Press
تصنيف البحث
1
عدد البحث
34
موقع البحث
NULL
سنة البحث
2016