Sertraline is effective in treatment of irritable bowel syndrome especially on those who have comorbid depression and/or anxiety. It is recommended to be used in recently diagnosed patients and those with predominant constipation IBS. Further trials needed to discuss the role of sertraline in IBS with exclusion of depression and anxiety. Also, longer duration and larger sample size are needed to be considered in further trials to detect complete relief of symptoms and symptoms relapse if happened.