Abstract The aim of this work was to quantify CD4+ CD25+ Foxp3+ T cells (Tregs) in Egyptian children with SLE and to correlate these findings with their disease activity scores and drug therapy. We enrolled 37 Egyptian children with active SLE. Disease activity was assessed by measuring serum levels of anti-dsDNA antibody and by the SLEDAI scores. Twenty healthy children were also enrolled as normal controls. The CD4+ CD25+, CD4+ CD25 bright, and CD4+ CD25 dim cells in patients were significantly increased in