Purpose

To retrospectively evaluate tumor response, local tumor control, and patient survival after the treatment of pulmonary metastases using transpulmonary chemoembolization (TPCE) in palliative and neoadjuvant intent.

Materials and methods

One hundred forty-three patients (mean age 56.7 ± 13.4 years) underwent repetitive TPCE (mean number of sessions 5.8 ± 2.9) between June 2005 and April 2017 for the treatment of unresectable lung metastases, not responding to systemic chemotherapy. Patients had predominant lung metastases with bilateral lung involvement in 80.4% of the cases. Regional delivery of the chemotherapeutic agents was performed through selective catheterization of the tumor-supplying pulmonary arteries with subsequent injection of iodized oil and microspheres. Patients, who underwent subsequent ablation (n = 51), either for all lesions (complete) or dominant lesions …

Breast cancer is the most common life-threatening cancer in women worldwide. A high number of women are going through biopsy procedures for characterization of breast masses every day and yet 75% of the pathological results prove these masses to be benign. Ultrasound (US) elastography is a non-invasive technique that measures tissue stiffness. It is convenient for differentiating benign from malignant breast tumors. Our study aims to evaluate the role of qualitative ultrasound elastography scoring (ES), quantitative mass strain ratio (SR), and shear wave elasticity ratio (SWER) in differentiation between benign and malignant breast lesions.

Results

Among 51 female patients with 77 histopathologically proved breast lesions, 57 breast masses were malignant and 20 were benign. All patients were examined by B-mode ultrasound then strain and shear wave elastographic examinations using …

The diagnosis of breast cancer is based on a clinical examination, sono-mammography, and magnetic resonance imaging. Mammography is considered a key tool in the diagnosis and early identification of breast cancer. However, a quarter of malignant cases are missed by using mammographic screening alone. Contrast-enhanced digital mammography (CEDM) has increased the opportunity for early detection and better Breast Imaging-Reporting and Data System (BI-RADS). assessment of breast cancer patients.

Results

This prospective study included 115 patients, 75% were malignant and 25% were benign. Full-field digital mammography (FFDM) and CEDM were performed using the FUJIFILM Innovality mammography machine unit. The receiver operating characteristic (ROC) curve and Youden index analysis showed increased overall diagnostic performance of CEDM over FFDM alone, with the area under the curve (AUC) of 0.900 versus 0.755 (P = 0.0020). CEDM showed increased specificity 80% versus 65%, sensitivity 94.7% versus 86%, and accuracy 88.3% versus 80.5% (P <0.001) compared to FFDM alone. The calculated accuracy of CEDM in the detection of the multiplicity of malignant lesions was increased by 44.4% versus 27% compared to FFDM alone. CEDM improved the BI-RADS categorization of breast lesions and increased the accuracy in the detection of bilateral malignant breast lesions by 8.3% versus 5.5% compared to FFDM.

Conclusion

CEDM is a more potent imaging modality than FFDM alone in the discrimination between benign and malignant breast lesions, it improves the accuracy of BI-RADS …

Pathological nipple discharge (PND) commonly caused by benign diseases, but occasionally it signifies a major medical concern. Ultrasonography, in addition to mammography, is regarded as the standard imaging modality in the diagnosis of PND but their sensitivity in some cases are low, subsequently we used a contrast enhanced mammography (CEDM) as supplementary diagnostic modality in patients with PND. The purpose of our study was to investigate the diagnostic efficacy of CEDM in evaluating PND patients, added values of incorporating the CEDM in the diagnostic workup of patients with PND and to demonstrate its diagnostic significance as a predictor of malignancy in these patients as there have been few studies that have addressed the role of CEDM in the evaluation of PND.

Results

Forty seven patients with PND were enrolled in this prospective study and underwent CEDM. The …

Gastric cancer stands as one of the most prevalent malignancies globally, conventional endoscopic specimens have been the primary means of diagnosing preoperative gastric histopathology, however, their limitations in capturing intra-tumor heterogeneity compromise their efficacy in evaluating angiogenesis. Perfusion Computed Tomography (P-CT) emerges as a pivotal functional imaging modality, facilitating objective assessment of tissue perfusion, serving as a marker of angiogenesis. So, our research objective was to evaluate the efficacy of CT perfusion imaging in the prediction of histological grades of gastric tumors using quantitative perfusion parameters such as permeability surface (PS), blood flow (BF), mean transient time (MTT), and blood volume (BV), in addition to the qualitative scoring system then comparing the findings with the histopathological results.