Calcifying nested stromal-epithelial tumour (CNSET) of the liver is a rare tumour, recently included in the WHO Classification of Digestive system Tumours 2019. Its hallmark is the nested proliferation of epithelial and spindle cells with surrounding desmoplastic stroma, calcifications and ossifications. Less than 40 cases have been reported, whereas none has been reported in Middle Eastern descendants. We report the first case of CNSET in a 22-year-old Egyptian lady with detailed histological and clinical data.

Extra-skeletal osteosarcoma (ESOS) is a rare neoplasm that represents less than 2% of all soft tissue sarcomas. Common reported sites of involvement include limbs, retroperitoneum, chest wall and buttocks. ESOS arising primarily in parenchymatous organs are extremely uncommon, with the involvement of the urinary bladder is even rarer. We herein report a case of primary ESOS of the urinary bladder in a 48 year-old male patient.

Invasive lobular carcinoma of the breast is the second most common type of invasive breast carcinoma. Invasive lobular carcinoma has an unusual pattern of metastases, which poses a diagnostic challenge for both clinicians and pathologists. We herein present three cases of breast invasive lobular carcinoma presented with metastasis to unusual sites, namely, uterus, colon and stomach. We recommend a higher index of suspicion in any case with breast cancer developing gastrointestinal tract or genital tract symptoms.