Neoadjuvant chemotherapy is the standard care for locally advanced breast cancer. Our study aimed at evaluating the feasibility of breast conversation surgery (BCS) after neoadjuvant chemotherapy. Patients and methods: Forty five patients had stage IIB (except those with T2N1 disease) and stage IIIA were selected to 3 cycles taxane-based neoadjuvant chemotherapy. Patient who had tumours≤ 5 cm underwent a tentative BCS while patients who had tumour size> 5 cm underwent radical surgery. Negative margin is .

Abstract Recent studies indicate an ectopic upregulation of the human leukocyte antigen G (HLA-G) in tumor cells that may favor their escape from antitumor immune responses. The role of HLA-G in breast cancer has not been defined. Other studies showed that HLA-G transcription may be silenced by epigenetic mechanisms or activated by stress. This work aimed to clarify the expression of HLA-G protein, estimate the possible prognostic role of HLA-G expression and identify if this expression is linked to the DNA index (DI) and S

Background: The use of shorter radiotherapy schedules has an economic and logistic advantage for radiotherapy departments, as well as a high degree of patient convenience. The aim of this study is to assess the acute and short-term late toxicities of a hypofractionated radiotherapy schedule with a concomitant boost. Methods: We enrolled 57 eligible patients as group A. These patients received 42.5 Gy in 16 fractions of 2.66 Gy each to the whole breast over 3.2 weeks. A concomitant electron boost of 12 Gy in 16 fractions

Background: Diffuse large B-cell lymphoma (DLBCL) is commonest pathological type of gastrointestinal lymphoma and its management was changed from surgery to combined chemoimmunotherapy in the last decade however this strategy is questionable especially if rituximab is not available. Methods: 79 files were reviewed retrospectively. We divided the patients into 2 groups; (group-1) Included 37 patients who underwent surgery followed by chemotherapy and (group -2) included 42 patients who received chemotherapy .The indication of surgery was mainly due to obstruction/perforation. We compared the efficacy of using surgery between the 2 groups and between primary anatomical site subgroups regarding their PFS and OS. Results: We found using surgery before chemotherapy was superior to chemotherapy alone in term DFS p= 0.012 and OS p=0.037. But in the anatomical subgroups analysis, it did not show any significant difference in primary gastric lymphoma (PGL) regarding DFS and OS p=0.706, p=0.858, in contrary, we found significant improvement in PFS and OS p=0.032, p=0.025 in primary intestinal lymphoma (PIL) favoring use surgical approach. Conclusion Surgery is still an important strategy in case of DLBCL in PIL intestinal lymphoma however in case of PGL using chemotherapy even without rituximab achieve similar results. However our small sample size should be considered.