Address: 1Department of Pediatric Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, 2Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt and 3Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt Email: Nisreen M Khalifa - nisreen_khalifa@hotmail.com; Doaa W Maximous - doaadavid@hotmail.com; Alaa A Abd- Elsayed* - alaaawny@hotmail.com * Corresponding author ... Abstract Introduction

Address: 1Department of Pediatric Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt, 2Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt and 3Department of Public Health and Community Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt Email: Nisreen M Khalifa - nisreen_khalifa@hotmail.com; Doaa W Maximous - doaadavid@hotmail.com; Alaa A Abd- Elsayed* - alaaawny@hotmail.com * Corresponding author ... Abstract Introduction

Neoadjuvant chemotherapy is the standard care for locally advanced breast cancer. Our study aimed at evaluating the feasibility of breast conversation surgery (BCS) after neoadjuvant chemotherapy. Patients and methods: Forty five patients had stage IIB (except those with T2N1 disease) and stage IIIA were selected to 3 cycles taxane-based neoadjuvant chemotherapy. Patient who had tumours≤ 5 cm underwent a tentative BCS while patients who had tumour size> 5 cm underwent radical surgery. Negative margin is .

Abstract Recent studies indicate an ectopic upregulation of the human leukocyte antigen G (HLA-G) in tumor cells that may favor their escape from antitumor immune responses. The role of HLA-G in breast cancer has not been defined. Other studies showed that HLA-G transcription may be silenced by epigenetic mechanisms or activated by stress. This work aimed to clarify the expression of HLA-G protein, estimate the possible prognostic role of HLA-G expression and identify if this expression is linked to the DNA index (DI) and S