Research Abstract
Background: We conducted a retrospective analysis to evaluate overall survival
(OAS) and disease free survival (DFS) rates in patients with squamous cell carcinoma
of the urinary bladder according to different prognostic factors.
Methods: This retrospective study analyzed the medical records of patients with
non-metastatic squamous cell carcinoma of the urinary bladder. All men underwent
radical cystectomy and women underwent anterior pelvic exentration. Most patients
had postoperative radiation therapy. The log-rank test examined differences in OAS
and DFS rates.
Results: The medical records of 106 patients were analyzed. The median followup
from the date of enrollment was 30 months and ranged from 2 to 73 months. For
the entire group, three-year OAS rates were 46.9% and DFS rates were 44%. For patients
with P2 (tumor invasion into the muscularis propria) the three-year OAS rate was 53%,
for P3 (tumor invasion into perivesical fat) it was 45% and 9% for P4 (tumor invasion
into adjacent organs, pelvic wall or abdominal wall) The OAS rate was statistically
significant in favor of P2 disease (P=0.0041). The three-year DFS rate was 50% for
P2, 45% for P3 and 9% for P4 disease (P=0.0125). Administration of post-operative
radiotherapy did not result in statistically significant improvement in three-year OAS
and DFS rates.
Conclusion: Survival rates were statistically significant and higher in patients
with P2 and P3 disease compared to P4 disease. Adjuvant radiotherapy did not result
in statistically significant survival improvement.
Keywords: Survival analysis, Squamous cell carcinoma, Bladder
Received: February
