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Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Research Abstract
Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.
Research Authors
Engy Shafik, Dina Ahmed Mohareb, Helal Hetta, Abd el-Rady, Zainab Gaber, Mohamed Zakaria Abu Rahma, Wael A Abbas, Haisam Atta
Research Journal
International Journal of Cancer and Biomedical Research
Research Pages
121-131
Research Publisher
The Egyptian Association for Cancer Research (EACR)
Research Rank
2
Research Vol
4-2
Research Website
https://journals.ekb.eg/article_96233.html
Research Year
2020

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Research Abstract
Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.
Research Authors
Engy Shafik, Dina Ahmed Mohareb, Helal Hetta, Abd el-Rady, Zainab Gaber, Mohamed Zakaria Abu Rahma, Wael A Abbas, Haisam Atta
Research Journal
International Journal of Cancer and Biomedical Research
Research Pages
121-131
Research Publisher
The Egyptian Association for Cancer Research (EACR)
Research Rank
2
Research Vol
4-2
Research Website
https://journals.ekb.eg/article_96233.html
Research Year
2020

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Research Abstract
Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.
Research Authors
Engy Shafik, Dina Ahmed Mohareb, Helal Hetta, Abd el-Rady, Zainab Gaber, Mohamed Zakaria Abu Rahma, Wael A Abbas, Haisam Atta
Research Journal
International Journal of Cancer and Biomedical Research
Research Pages
121-131
Research Publisher
The Egyptian Association for Cancer Research (EACR)
Research Rank
2
Research Vol
4-2
Research Website
https://journals.ekb.eg/article_96233.html
Research Year
2020

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Research Abstract
Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.
Research Authors
Engy Shafik, Dina Ahmed Mohareb, Helal Hetta, Abd el-Rady, Zainab Gaber, Mohamed Zakaria Abu Rahma, Wael A Abbas, Haisam Atta
Research Department
Research Journal
International Journal of Cancer and Biomedical Research
Research Member
Research Pages
121-131
Research Publisher
The Egyptian Association for Cancer Research (EACR)
Research Rank
2
Research Vol
4-2
Research Website
https://journals.ekb.eg/article_96233.html
Research Year
2020

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Research Abstract
Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.
Research Authors
Engy Shafik, Dina Ahmed Mohareb, Helal Hetta, Abd el-Rady, Zainab Gaber, Mohamed Zakaria Abu Rahma, Wael A Abbas, Haisam Atta
Research Department
Research Journal
International Journal of Cancer and Biomedical Research
Research Pages
121-131
Research Publisher
The Egyptian Association for Cancer Research (EACR)
Research Rank
2
Research Vol
4-2
Research Website
https://journals.ekb.eg/article_96233.html
Research Year
2020

Adipocytokine, leptin, and resistin in combination with quantitative visceral adiposity as predictors of colorectal neoplasm: A case-control study

Research Abstract
Background: Substantial evidence has supported the association between adipocytokines and many types of cancers. However, the results in the setting of colorectal cancer (CRC) remains conflicting. Aim: This study aimed to evaluate the predictive power of adipocytokines (leptin and Rrsistin) levels and abdominal fat distribution in the diagnosis of colorectal cancer. Methods: Eighty participants were recruited then divided into three groups based on the endoscopic and histopathological investigation. The recruited individuals included 30 patients with colon cancer, 25 with colonic adenoma, and 25 controls. Serum adipocytokines (leptin and resistin) levels were measured, and the quantitative fat analysis was calculated based on an abdominal CT scan. Results: Multivariable logistic regression revealed that two predictors (leptin and resistin) of CRC development could be used. Visceral/superficial fat rate was the most significant predictor among the parameters of quantitative fat analysis. Also, psoas muscle and visceral fat volume showed significant differences among the study groups. Conclusion: Leptin and resistin can be used as a valuable independent predictor for the diagnosis of colorectal cancer. Also, the visceral/superficial fat rate was the most predictor.
Research Authors
Engy Shafik, Dina Ahmed Mohareb, Helal Hetta, Abd el-Rady, Zainab Gaber, Mohamed Zakaria Abu Rahma, Wael A Abbas, Haisam Atta
Research Department
Research Journal
International Journal of Cancer and Biomedical Research
Research Member
Research Pages
121-131
Research Publisher
The Egyptian Association for Cancer Research (EACR)
Research Rank
2
Research Vol
4-2
Research Website
https://journals.ekb.eg/article_96233.html
Research Year
2020

Secondary signs of ligamentum teres injuries. A non-arthrographic and arthrographic MR findings correlation

Research Abstract
Purpose To assess the value of secondary signs in helping to diagnose ligamentum teres (LT) injuries. Materials and methods Seventy-nine patients enrolled in a prospective case-control study performed MRI examination of the hip joints. Two groups identified according to their clinical presentation. Group I [54 patients] with clinically suspicious LT injury, Group II [25 patients] with no clinical suspicion of such diagnosis considered as control group examining both hip joints [total 50 examined joints]. Patients of the 1st group performed sonar-guided MR arthrography. Secondary MR signs are correlated with the occurrence of LT injuries. Consensus Diagnosis employs a 5 point confidence score. Results Thirty-one cases show LT injuries in which Bone marrow edema, joint effusion, and coincidental intra-articular pathology was found in 77%, 29% and 19% of cases respectively with (p-value ≤0.001). The combined secondary signs are present in 83% of cases with LT injuries (p ≤ 0.001). The significant alteration in dimensions is in width with mean cut off 4.9 mm of injured LT with 87% specificity. Almost perfect agreement (K = 0.91, p ≤ 0.001) recorded in the consensus interpretation between the two radiologists. Conclusion The presence of the secondary signs of LT injury raises the suspicion for such diagnosis.
Research Authors
Haisam Atta, Amr F Mourad, Essam Elmorshidy, Mohamed Mahran
Research Journal
The Egyptian Journal of Radiology and Nuclear Medicine
Research Pages
674-680
Research Publisher
Elsevier
Research Rank
1
Research Vol
49-3
Research Website
https://www.sciencedirect.com/science/article/pii/S0378603X18300676
Research Year
2018

Secondary signs of ligamentum teres injuries. A non-arthrographic and arthrographic MR findings correlation

Research Abstract
Purpose To assess the value of secondary signs in helping to diagnose ligamentum teres (LT) injuries. Materials and methods Seventy-nine patients enrolled in a prospective case-control study performed MRI examination of the hip joints. Two groups identified according to their clinical presentation. Group I [54 patients] with clinically suspicious LT injury, Group II [25 patients] with no clinical suspicion of such diagnosis considered as control group examining both hip joints [total 50 examined joints]. Patients of the 1st group performed sonar-guided MR arthrography. Secondary MR signs are correlated with the occurrence of LT injuries. Consensus Diagnosis employs a 5 point confidence score. Results Thirty-one cases show LT injuries in which Bone marrow edema, joint effusion, and coincidental intra-articular pathology was found in 77%, 29% and 19% of cases respectively with (p-value ≤0.001). The combined secondary signs are present in 83% of cases with LT injuries (p ≤ 0.001). The significant alteration in dimensions is in width with mean cut off 4.9 mm of injured LT with 87% specificity. Almost perfect agreement (K = 0.91, p ≤ 0.001) recorded in the consensus interpretation between the two radiologists. Conclusion The presence of the secondary signs of LT injury raises the suspicion for such diagnosis.
Research Authors
Haisam Atta, Amr F Mourad, Essam Elmorshidy, Mohamed Mahran
Research Journal
The Egyptian Journal of Radiology and Nuclear Medicine
Research Pages
674-680
Research Publisher
Elsevier
Research Rank
1
Research Vol
49-3
Research Website
https://www.sciencedirect.com/science/article/pii/S0378603X18300676
Research Year
2018

Secondary signs of ligamentum teres injuries. A non-arthrographic and arthrographic MR findings correlation

Research Abstract
Purpose To assess the value of secondary signs in helping to diagnose ligamentum teres (LT) injuries. Materials and methods Seventy-nine patients enrolled in a prospective case-control study performed MRI examination of the hip joints. Two groups identified according to their clinical presentation. Group I [54 patients] with clinically suspicious LT injury, Group II [25 patients] with no clinical suspicion of such diagnosis considered as control group examining both hip joints [total 50 examined joints]. Patients of the 1st group performed sonar-guided MR arthrography. Secondary MR signs are correlated with the occurrence of LT injuries. Consensus Diagnosis employs a 5 point confidence score. Results Thirty-one cases show LT injuries in which Bone marrow edema, joint effusion, and coincidental intra-articular pathology was found in 77%, 29% and 19% of cases respectively with (p-value ≤0.001). The combined secondary signs are present in 83% of cases with LT injuries (p ≤ 0.001). The significant alteration in dimensions is in width with mean cut off 4.9 mm of injured LT with 87% specificity. Almost perfect agreement (K = 0.91, p ≤ 0.001) recorded in the consensus interpretation between the two radiologists. Conclusion The presence of the secondary signs of LT injury raises the suspicion for such diagnosis.
Research Authors
Haisam Atta, Amr F Mourad, Essam Elmorshidy, Mohamed Mahran
Research Department
Research Journal
The Egyptian Journal of Radiology and Nuclear Medicine
Research Member
Research Pages
674-680
Research Publisher
Elsevier
Research Rank
1
Research Vol
49-3
Research Website
https://www.sciencedirect.com/science/article/pii/S0378603X18300676
Research Year
2018

Secondary signs of ligamentum teres injuries. A non-arthrographic and arthrographic MR findings correlation

Research Abstract
Purpose To assess the value of secondary signs in helping to diagnose ligamentum teres (LT) injuries. Materials and methods Seventy-nine patients enrolled in a prospective case-control study performed MRI examination of the hip joints. Two groups identified according to their clinical presentation. Group I [54 patients] with clinically suspicious LT injury, Group II [25 patients] with no clinical suspicion of such diagnosis considered as control group examining both hip joints [total 50 examined joints]. Patients of the 1st group performed sonar-guided MR arthrography. Secondary MR signs are correlated with the occurrence of LT injuries. Consensus Diagnosis employs a 5 point confidence score. Results Thirty-one cases show LT injuries in which Bone marrow edema, joint effusion, and coincidental intra-articular pathology was found in 77%, 29% and 19% of cases respectively with (p-value ≤0.001). The combined secondary signs are present in 83% of cases with LT injuries (p ≤ 0.001). The significant alteration in dimensions is in width with mean cut off 4.9 mm of injured LT with 87% specificity. Almost perfect agreement (K = 0.91, p ≤ 0.001) recorded in the consensus interpretation between the two radiologists. Conclusion The presence of the secondary signs of LT injury raises the suspicion for such diagnosis.
Research Authors
Haisam Atta, Amr F Mourad, Essam Elmorshidy, Mohamed Mahran
Research Department
Research Journal
The Egyptian Journal of Radiology and Nuclear Medicine
Research Member
Research Pages
674-680
Research Publisher
Elsevier
Research Rank
1
Research Vol
49-3
Research Website
https://www.sciencedirect.com/science/article/pii/S0378603X18300676
Research Year
2018
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