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Our study concluded that statistically significant differences exist between metastatic RCC and LCC in terms of age at diagnosis, gender predilection, presenting symptoms, histo-pathology and differentiation, sites of metastases, KRAS status, and response to first-line treatment with chemotherapy plus anti-EGFR therapy. Our study is compatible with the results of most of the recent international studies and now there is a global trend for considering RCC and LCC as a two separate diseases. Further research should be done worldwide for more evaluation of the differences between RCC and LCC especially as regards molecular phenotyping and the response to targeted therapy and immunotherapy.

Our study concluded that statistically significant differences exist between metastatic RCC and LCC in terms of age at diagnosis, gender predilection, presenting symptoms, histo-pathology and differentiation, sites of metastases, KRAS status, and response to first-line treatment with chemotherapy plus anti-EGFR therapy. Our study is compatible with the results of most of the recent international studies and now there is a global trend for considering RCC and LCC as a two separate diseases. Further research should be done worldwide for more evaluation of the differences between RCC and LCC especially as regards molecular phenotyping and the response to targeted therapy and immunotherapy.

Our study concluded that statistically significant differences exist between metastatic RCC and LCC in terms of age at diagnosis, gender predilection, presenting symptoms, histo-pathology and differentiation, sites of metastases, KRAS status, and response to first-line treatment with chemotherapy plus anti-EGFR therapy. Our study is compatible with the results of most of the recent international studies and now there is a global trend for considering RCC and LCC as a two separate diseases. Further research should be done worldwide for more evaluation of the differences between RCC and LCC especially as regards molecular phenotyping and the response to targeted therapy and immunotherapy.

Purpose To evaluate the role of non-contrast multidetector CT (MDCT) reliability in localizing CSF leaks and skull base defects in correlation to operative findings. Materials and methods Twenty patients clinically diagnosed to have CSF rhinorrhea; 8 spontaneous and 12 post-traumatic patients were evaluated using 64-rows MDCT with slice section 0.6 mm. CT is considered accurate if correctly determine the site and size of bony defect as matched with operative findings. Results MDCT accurately detected the site of presumed CSF leak in 19 out of 20 cases with sensitivity 95%. Cribriform plate defect is the most common site of defect in 40% of cases with 75% of cases categorized as Keros type II. The consensus image with fair agreement (K = 0.38) shows that coronal reformat has the highest diagnostic performance in 75% of cases while the least diagnostic value is encountered with the axial plane in 15% of cases …

Purpose To evaluate the role of non-contrast multidetector CT (MDCT) reliability in localizing CSF leaks and skull base defects in correlation to operative findings. Materials and methods Twenty patients clinically diagnosed to have CSF rhinorrhea; 8 spontaneous and 12 post-traumatic patients were evaluated using 64-rows MDCT with slice section 0.6 mm. CT is considered accurate if correctly determine the site and size of bony defect as matched with operative findings. Results MDCT accurately detected the site of presumed CSF leak in 19 out of 20 cases with sensitivity 95%. Cribriform plate defect is the most common site of defect in 40% of cases with 75% of cases categorized as Keros type II. The consensus image with fair agreement (K = 0.38) shows that coronal reformat has the highest diagnostic performance in 75% of cases while the least diagnostic value is encountered with the axial plane in 15% of cases …