Calcifying nested stromal-epithelial tumour (CNSET) of the liver is a rare tumour, recently included in the WHO Classification of Digestive system Tumours 2019. Its hallmark is the nested proliferation of epithelial and spindle cells with surrounding desmoplastic stroma, calcifications and ossifications. Less than 40 cases have been reported, whereas none has been reported in Middle Eastern descendants. We report the first case of CNSET in a 22-year-old Egyptian lady with detailed histological and clinical data.
Extra-skeletal osteosarcoma (ESOS) is a rare neoplasm that represents less than 2% of all soft tissue sarcomas. Common reported sites of involvement include limbs, retroperitoneum, chest wall and buttocks. ESOS arising primarily in parenchymatous organs are extremely uncommon, with the involvement of the urinary bladder is even rarer. We herein report a case of primary ESOS of the urinary bladder in a 48 year-old male patient.
Invasive lobular carcinoma of the breast is the second most common type of invasive breast carcinoma. Invasive lobular carcinoma has an unusual pattern of metastases, which poses a diagnostic challenge for both clinicians and pathologists. We herein present three cases of breast invasive lobular carcinoma presented with metastasis to unusual sites, namely, uterus, colon and stomach. We recommend a higher index of suspicion in any case with breast cancer developing gastrointestinal tract or genital tract symptoms.
The immunoscore (ISc) has been extensively investigated as a prognostic indicator for numerous solid tumors. In renal cell carcinoma (RCC), its prognostic significance has been evaluated in a small number of studies. This study was designed to ascertain the prognostic value of ISc based on CD3+ and CD8+ T cells in patients with RCC. This study included 115 non-metastatic RCC patients who underwent nephrectomy. The ISc was obtained by estimating the densities of CD3+ and CD8+ cells at the invasive margin and center of the tumor using two methods: cell count per square millimeter (cell count/mm2) and percentage of cells per square millimeter (% of cells/mm2). The patients were categorized into low and high groups according to the ISc. The associations between the ISc and clinicopathological characters, including survival, were analyzed statistically. Adverse clinicopathologic factors were significantly …
The objective of this study is to determine the prognostic implications of PBRM1 immunohistochemical (IHC) expression in renal cell carcinoma (RCC) patients. Additionally, the objective is extended to evaluate the association between PBRM1 expression and CD3 + and CD8 + immune infiltrates. This study retrospectively reviewed 115 RCC patients who underwent nephrectomy. Immunohistochemistry was performed for PBRM1, CD3, and CD8. The associations between the studied parameters and variable clinicopathological characteristics, including survival, were analyzed statistically. A significant association was observed between the low expression of PBRM1 (< 50 %) and aggressive clinicopathologic features (p value around 0.001), as well as a significantly worse 3-year overall survival (OS) and disease-free survival (DFS) (p value around 0.001). PBRM1 low expression was considered an …
Background
Atesting for neuroendocrine markers during breast cancer diagnosis is rarely required. Also, breast cancer with neuroendocrine differentiation is highly under presented in clinical trials.
Objective
This research aimed to study patients with triple negative breast cancer (TNBC) with neuroendocrine differentiation to outline their characteristics and outcomes.
Patients and methods
We examined effect of synaptophysin expression and other clinicopathological features of 35 non-metastatic triple negative breast cancer females for disease free survival (DFS) and overall survival (OS).
Results
There was a statistically significant association between synaptophysin-enriched expression and tumor infiltrating lymphocytes (TILs) > 50% in TNBC patients (P= 0.047). Stage III disease, tumor size ≥ T3, high Ki67 and presence of ductal carcinoma in situ (DCIS) were significantly associated with decreased DFS. Tumor size ≥ T3 and high Ki67 were bad prognostic factors for overall survival. Of note, Ki67 was the sole independent prognostic factor predicting DFS and OS.
Conclusion
There is a clear association between synaptophysin expression and increased TILs percentage in TNBC raising the possible benefit of immunotherapy in this category of breast cancer, however, further study with larger sample size is needed for outlining the survival effects of synaptophysin expression.
