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Safety and Efficacy of Ultrasound-Guided Combined Segmental Thoracic Spinal Epidural Anesthesia in Abdominal Surgeries and Laparoscopic Procedures: A Prospective Randomized Clinical Study

Research Abstract

Thoracic segmental spinal anesthesia (SA) may be a good alternative to general anesthesia (GA) for abdominal operations and laparoscopic procedures, especially in high-risk patients.

Objectives

The aim of this study was to investigate the safety and efficacy of thoracic segmental SA vs GA during abdominal operations and laparoscopic procedures.

Methods

This study was conducted at our university hospital and involved a total of 46 patients who underwent abdominal operations and laparoscopic procedures. The study period spanned from January 15, 2022, to October 15, 2022. Patients were divided into 2 groups: Group 1 (n = 23) received standard GA, and group 2 (n = 23) received thoracic segmental SA. A combination of 10 mg of hyperbaric bupivacaine 0.5% and 25 μg of fentanyl was injected through the spinal needle. The epidural catheter was then threaded through the Tuohy needle after withdrawal of the spinal needle to keep only 4 cm up in the epidural space. Demographic data, both intra and postoperative hemodynamic parameters, were monitored. Postoperatively, pain in both groups was treated with intravenous (IV) morphine by patient controlled analgesia (PCA), PCA settings were 1 mg morphine/mL, no background infusion, bolus dose 2 mL and lockout interval 15 min. Postoperative, both resting VAS and VAS during cough were measured for all patients at fixed intervals, and all patients were followed up for postoperative complications.

Results

No significant variation was found in demographic data. Intra and postoperative mean arterial pressure (MAP) and heart rate (HR) measurements were higher in group 1 than in group 2 but without a statistically significant difference (P < 0.029). Early postoperative VAS values and discharge time from the postanesthesia care unit (PACU) were significantly reduced in group 2 than in group 1 (P < 0.001). The number of patients asked for analgesia and total opioid consumption were substantially reduced in group 2 than in group 1. Also, the time of the first analgesia request and patient satisfaction were substantially greater in group 2 than in group 1.

Conclusions

Combined thoracic spinal/epidural block results in stable hemodynamics, longer postoperative analgesia with fewer side effects, and greater surgeon and patient satisfaction in patients undergoing abdominal operations and laparoscopic procedures.

Keywords: Combined Thoracic Spinal Epidural, General Anesthesia, Laparoscopic Surgeries, Acute Pain, VAS Scores

Research Authors
Alaa Ali M Elzohry 1,*, Ahmed S Hegab 2, Osama Yehia A Khalifa 2, Khadeja M Elhossieny 2, Fatma Al Zahraa H Abdel Hameed 1
Research Journal
Anesthesiology and Pain Medicine
Research Member
Research Publisher
Wiley

Exploring Hepatitis C as a Relapse Risk Factor in Pediatric Acute Lymphoblastic Leukemia: A Study From a Resource‐Limited Egyptian Setting

Research Abstract


Exploring Hepatitis C as a Relapse Risk Factor in Pediatric Acute Lymphoblastic Leukemia: A Study From a Resource‐Limited Egyptian Setting

Research Date
Research Year
2025

Two Surveys, 16 Years Apart: Comparing Traditional and Complementary Medicine Use by Children With Cancer in Jordan

Research Abstract

Traditional and complementary medicine (T&CM) is commonly used by children with cancer alongside conventional treatments. However, data on its use in Jordan remain limited. This study aimed to assess the current prevalence, types, motivations, and disclosure rates of T&CM use in Jordan, and to compare these findings with those from the original 2008 study conducted in the same setting.

Research Date
Research Department
Research Year
2025

Comparison between ultrasound guided erector spinae plane block and paravertebral block on acute and chronic post mastectomy pain after modified radical mastectomy: randomized …

Research Authors
Samy Abdelrahman Amr, Ahmed Hassan Othman, Eman Hassan Ahmed, Romany Gergis Naeem, Shereen Mamdouh Kamal
Research Date
Research Journal
BMC anesthesiology
Research Member
Research Publisher
BioMed Central
Research Year
2024

Safety and Complications of Totally Implantable Venous Access Devices in Pediatric Patients with Cancer at South Egypt Cancer Institute

Novel tetrahydroisoquinolines as DHFR and CDK2 inhibitors: synthesis, characterization, anticancer activity and antioxidant properties

Research Abstract

In this study, we synthesized new 5,6,7,8-tetrahydroisoquinolines and 6,7,8,9-tetrahydrothieno[2,3-c]isoquinolines based on 4-(N,N-dimethylamino)phenyl moiety as expected anticancer and/or antioxidant agents. The structure of all synthesized compounds were confirmed by spectral date (FT-IR, 1H NMR, 13C NMR) and elemental analysis. We evaluated the anticancer activity of these compounds toward two cell lines: A459 cell line (lung cancer cells) and MCF7 cell line (breast cancer cells). All tested compounds showed moderate to strong anti-cancer activity towards the two cell lines. Compound 7e exhibited the most potent cytotoxic activity against A549 cell line (IC50: 0.155 µM) while compound 8d showed the most potent one against MCF7 cell line (IC50: 0.170 µM) in comparison with doxorubicin. In addition, we examined the effect of compounds 7e and 8d regarding the growth of A549 and MCF7 cell lines, employing flow cytometry and Annexin V-FITC apoptotic assay. Our results showed that compound 7e caused cell cycle arrest at the G2/M phase with a 79-fold increase in apoptosis of A459 cell line. Moreover, compound 8d caused cell cycle arrest at the S phase with a 69-fold increase in apoptosis of MCF7 cell line. Furthermore, we studied the activity of these compounds as enzyme inhibitors against several enzymes. Our findings by docking and experimental studies that compound 7e is a potent CDK2 inhibitor with IC50 of 0.149 µM, compared to the Roscovitine control drug with IC50 of 0.380 µM. We also found that compound 8d is a significant DHFR inhibitor with an IC50 of 0.199 µM, compared to Methotrexate control drug with IC50 of 0.131 µM. Evaluation of the antioxidant properties of ten compounds was also studied in comparison with Vitamin C. Compounds 1367c and 8e have higher antioxidant activity than Vitamin C which mean that these compounds can used as potent antioxidant drugs.

Research Authors
سلمى جمال عبدالمالك مرسي
Research Date
Research Department
Research Journal
BMC chemistry

Predictive Factors of Severe Adverse Events in Pediatric Oncology Patients with Febrile Neutropenia at South Egypt Cancer Institute

Research Authors
Mohamed S. Ahmed Amany M. Ali, Khaled F. Ryad, Asmaa M. Zahran, Mahmod M. Elzembely
Research Date
Research Department
Research Member
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