Progesterone receptor alpha (PRA) has a central coordinator role in the ovarian functionsin mammals. The aim of this study was to investigate the immunolocalization of PRA in therabbit ovary during pregnancy and after parturition. The rabbit ovary during pregnancy andafter parturition had moderate cytoplasmic and moderate to intense nuclear PRA immunos-taining in the ovarian surface epithelial cells, stromal cells and interstitial gland cells. ThePRA was also present in granulosa cells and theca interna cells of the growing, small antraland mature Graafian follicles. Theca interna cells of the atretic antral follicle in addition toendothelial and fibroblast cells had PRA immunoreactivity. The PRA were also observed inthe theca externa smooth muscle-like cells of the growing and antral follicles and in thetelocytes. In the present study, the corpora haemorrhagica and early developing corporalutea had, slight cytoplasmic and nuclear PRA immunostaining in the large lutein and smalllutein cells. The endothelial cells of the corpora haemorrhagica and corpora lutea had anintense nuclear PRA immune signal. The corpora lutea at an advanced stage of develop-ment had moderate cytoplasmic and nuclear PRA immunostaining in the large lutein cellsand intense nuclear PRA immunostaining in the small lutein cells. The regressed corporalutea did not have PRA immunostaining in the apoptotic large lutein cells and moderatecytoplasmic and intense nuclear PRA immunostaining in the small lutein cells.

NULL

4- Nonylphenol (NP) toxicity in fish attracts much attention due to its ability in targeting several organs; however, the researches regarding its potential hepatotoxicity are conflict and still require further investigation. Therefore, the objective of this study is to focus on this issue from the histo-physiological point of view using NP intoxicated African catfish (Clarias garepinus) as a model of hepatotoxicity. 12 adult fish (6 per group) were divided into two groups; the first was considered as control and the second was exposed to NP dissolved in water at a dose of 0.1 mg/kg BW for 3 weeks. A significant reduction in the hepatic alanine aminotransferase, asparatate aminotransferase and lactate dehydrogenase levels was observed in NP exposed fish. Concerning the oxidant/antioxidant balance, a significant depletion in superoxide dismutase, catalase and glutathione peroxidase was found along with a significant elevation in total peroxide and malondialdhyde. The histopathological examination of the liver tissue revealed that NP had marked hepatotoxic effects including hepatitis, centrilobular and focal hydropic and fatty degeneration, fatty change (steatosis), apoptosis of hepatocytes and necrosis of endothelial cells, hepatic coagulative necrosis, and nuclear alterations. Depletion of the glycogen and increased in pigments (lipofuscin and hemosiderin) content in the hepatocytes were also recorded. Hemosiderosis and proliferation of the connective tissue around the blood vessels, branches of bile ducts and in the portal areas were also observed. In the light of these findings, it was concluded that NP has a well defined hepatotoxic impact in Clarias Gariepinus paving the road towards other studies investigate other detrimental cyto-physiological influences of this aquatic pollutant.

4- Nonylphenol (NP) toxicity in fish attracts much attention due to its ability in targeting several organs; however, the researches regarding its potential hepatotoxicity are conflict and still require further investigation. Therefore, the objective of this study is to focus on this issue from the histo-physiological point of view using NP intoxicated African catfish (Clarias garepinus) as a model of hepatotoxicity. 12 adult fish (6 per group) were divided into two groups; the first was considered as control and the second was exposed to NP dissolved in water at a dose of 0.1 mg/kg BW for 3 weeks. A significant reduction in the hepatic alanine aminotransferase, asparatate aminotransferase and lactate dehydrogenase levels was observed in NP exposed fish. Concerning the oxidant/antioxidant balance, a significant depletion in superoxide dismutase, catalase and glutathione peroxidase was found along with a significant elevation in total peroxide and malondialdhyde. The histopathological examination of the liver tissue revealed that NP had marked hepatotoxic effects including hepatitis, centrilobular and focal hydropic and fatty degeneration, fatty change (steatosis), apoptosis of hepatocytes and necrosis of endothelial cells, hepatic coagulative necrosis, and nuclear alterations. Depletion of the glycogen and increased in pigments (lipofuscin and hemosiderin) content in the hepatocytes were also recorded. Hemosiderosis and proliferation of the connective tissue around the blood vessels, branches of bile ducts and in the portal areas were also observed. In the light of these findings, it was concluded that NP has a well defined hepatotoxic impact in Clarias Gariepinus paving the road towards other studies investigate other detrimental cyto-physiological influences of this aquatic pollutant.

Ten mature virgin rabbit does (4-5 months old) with mean weight of 2.4 kg were induced to ovulate; by intramuscular injection of HCG (50-70 IU). The day of induction was considered 0 days. Uteri were obtained from 14 h, 3, 7, 18 days post induction. At first stage of pseudopregnancy; the two uteri became hyperemic and slightly swollen. The uterine epithelium and endometrial glands epithelium were of columnar type with oval basal nuclei. The endometrial glands were few in number and small in size. The endometrial glands showed apocrine activity. The uterus had six longitudinal folds and the uterine epithelium form crypts. The endometrium had slight vascularization. At middle stage of pseudopregnancy, the two uteri became hyperemic and more swollen. This stage characterized by; mucosal folding, glandular formation, epithelial proliferation and thickening of the uterine wall. At last stage of pseudopregnancy; the two uteri became flaccid and more swollen. This stage characterized by dramatic changes in the uterine architecture in the form of: increased epithelial proliferation and crypt formation increase the complexity of luminal folding, increase in length, size and abundance of the uterine endometrial glands, increase in the uterine micro vascular development (increased abundance of the large microvessels and development of subepithelial capillary plexuses). Tunica vascularis could be demonstrated between the inner circular and outer longitudinal smooth muscle fibers of the myometrium at the all stages of psedopregnancy. Telocytes with its characteristic morphology could be demonstrated in the myometrium of the rabbit uterus during pseudopregnancy. Cell-specific immuno-localization of progesterone receptors alpha (PRA) in the rabbit uterus during pseudopregnancy revealed that, there were mild, moderate and strong nuclear PRA immunostaining in the endometrial epithelial cells, endometrial glands and in the smooth muscles fibers of the myometrium of the first, middle and last stages of pseudopregnancy respectively.

It is well known that camels can live in severe environmental conditions and have ability to regulate its body temperature in such conditions. Previous studies indicated that skin is playing a pivotal role in thermoregulation and adaptation of the body to the surrounding environment. The aim of the current study is to investigate the role of the sweat glands of camel in their adaptation to the surrounding environment. The microstructure of the sweat glands in nine body regions of 10 camels has been studied. The sweat glands were found to be distributed in association with each primary hair follicle. Their ducts open into the upper portion of the hair follicle at a peculiar destination device. The correlated reliable function was discussed.

It is well known that camels can live in severe environmental conditions and have ability to regulate its body temperature in such conditions. Previous studies indicated that skin is playing a pivotal role in thermoregulation and adaptation of the body to the surrounding environment. The aim of the current study is to investigate the role of the sweat glands of camel in their adaptation to the surrounding environment. The microstructure of the sweat glands in nine body regions of 10 camels has been studied. The sweat glands were found to be distributed in association with each primary hair follicle. Their ducts open into the upper portion of the hair follicle at a peculiar destination device. The correlated reliable function was discussed.

It is well known that camels can live in severe environmental conditions and have ability to regulate its body temperature in such conditions. Previous studies indicated that skin is playing a pivotal role in thermoregulation and adaptation of the body to the surrounding environment. The aim of the current study is to investigate the role of the sweat glands of camel in their adaptation to the surrounding environment. The microstructure of the sweat glands in nine body regions of 10 camels has been studied. The sweat glands were found to be distributed in association with each primary hair follicle. Their ducts open into the upper portion of the hair follicle at a peculiar destination device. The correlated reliable function was discussed.

NULL

NULL