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The Protective Effects of Vitamin E and Zinc Supplementation Against Lithium-Induced Brain Toxicity of Male Albino Rats

Research Abstract
Lithium (Li) therapy has widely used in the treatment of bipolar disorder. Consequently, consciousness of the side effects and pathogenesis of this metal is needed for such treatments. Recently, information on the interaction of Li with oxidative markers and organs toxicity attend the researchers over the world. In the present study we have tried to evaluate the influence of oral administration of LiCl for 4 weeks on the oxidative stress marker and histological structure of brain in male rats. Fifty adult male albino rats weighing 135±15 gm was categorized into 5 groups (10 rats each). Group I worked as negative control, group II administrated with LiCl (0.20 mg/kg bw) in drinking water, group III, IV and V were administrated with Zn (10 mg/kg bw), VE (100 mg/kg bw) and their combination twice a week besides the daily administration of LiCl for 4 weeks, respectively. Rats after anesthesia with ether killed for collocation of brain for histopathological and biochemical analysis. Data obtained showed a significant increase in LPO, NO, GSH and Li content and the activities of SOD, CAT and AChE with demylination of the nerve fibers and degeneration of neurons in brain of LiCl treated rats. Co-treatment of ratswith Zn or VE results in a significant decrease in LPO, NO, GSH content in the activities of SOD, CAT and AChE with less or normal structure of the brain. However, co-treatment with combination of Zn and VE caused a significant increase in SOD, CAT and AChE activities with normal histological structure.In conclusion, the data from the present study show that Zn and VE and their interaction are effective in protection against Liinduced brain toxicity in rat with priority for the combination.
Research Authors
Ahmed Th. Ibrahim2
, Marwa A. Magdy2
, Emad A. Ahmed1
& Hossam M. Omar
Research Journal
Environment and Pollution
Research Pages
9-18
Research Publisher
Published by Canadian Center of Science and Education
Research Rank
1
Research Vol
4 ( 1)
Research Year
2015

Thymoquinone ameliorate testicular toxicity induced by acrylamide in rats

Research Abstract
The present study aims to evaluate the role of TQ on the oxidative damage induced by ACR in rat testes. The administration of ACR resulted in elevation in testes MDA and NO levels and significant reduction in the level of GSH and the activity of SOD and CAT. Also, plasma testosterone was significantly elevated in ACR-treated rats as compared with negative control. These biochemical changes were associated with congestion and interstitial edema,necrosis, calcification and degeneration of spermatogenic cells and formation of spermatid gaint cells. Co-treatment with TQ ameliorates these biochemical and histological changes. In conclusion, supplementation with TQ as antioxidant may offer protection against ACR induced testicular toxicity.
Research Authors
Hossam M. Omar, Sarry Kh Abdel-Ghafar, Imhemed O. Fiedana, Emad A. Ahmeda
Research Journal
The Journal of Free Radicals and Antioxidants. Photon
Research Pages
407-414
Research Rank
1
Research Vol
142
Research Website
https://sites.google.com/site/photonfoundationorganization/home/the-journal-of-free-radicals-and-antioxidants
Research Year
2014

L-cysteine ameliorated testicular toxicity induced
by acrylamide in rats

Research Abstract
The general public is exposed to acrylamide from industrial manufacturing, laboratory work, foods rich in carbohydrates that have been cooked at hightemperature,and through cigarette smoke. The present experiment was conducted to investigate the reproductive toxicity of acrylamide exposure in male rats and the role of L-cysteine supplementation in amelioration of this toxicity.
Research Authors
Hossam El-Din M. Omar1*, Sary Kh. Abd-elghafar2, Imhemed O. Fiedan1
and Emad A. Ahmed
Research Journal
European Journal of Biological Research
Research Pages
1-8
Research Publisher
TMKARPIŃSKI PUBLISHER
Research Rank
1
Research Vol
5 (2)
Research Website
www.journals.tmkarpinski.com/index.php/mmed
Research Year
2015

Radiative effect on natural convection flows in porous media

Research Abstract
Radiative effect on natural convection flows in porous media is studied
Research Authors
A.A.Mohammadian, M.A.Mansour, S.Abd El-Gaid and R.S.R.Gorla
Research Journal
Transport in Porous Media
Research Pages
1-10
Research Rank
1
Research Vol
32 (3)
Research Year
1998

Repeated magmatic pulses in the East African Orogen in the Eastern Desert, Egypt: An old idea supported by new evidence.

Research Authors
A. M. Lundmark, A. Andresen, M. A. Hassan, L. E. Augland and Gamal. Y. Boghdady
Research Journal
International Association for Gondwana Research. 22,1 227–237.
Research Pages
227–237.
Research Rank
1
Research Vol
International Geoscience Journal Gondwana Research
Research Year
2012

Anders Mattias Lundmark, Arild Andresen, Mohamed A. Hassan, Lars Eivind Augland, Mohamed Ali Abu El-Rus, Gamal Yehia Boghdady, (2010): Repeated magmatic pulses in the East African Orogen of Central Eastern Desert, Egypt: an old idea supported by new evide

Research Abstract
Lars Eivind Augland, Mohamed Ali Abu El-Rus, Gamal Yehia Boghdady, (2010): Repeated magmatic pulses in the East African Orogen of Central Eastern Desert, Egypt: an old idea supported by new evidence.
Research Authors
nders Mattias Lundmark, Arild Andresen, Mohamed A. Hassan, Lars Eivind Augland, Mohamed Ali Abu El-Rus, Gamal Yehia Boghdady
Research Journal
Journal of African Earth Sciences
Research Pages
520-580
Research Rank
1
Research Vol
Journal of African Earth Sciences
Research Year
2010

Application of Modified Bagasse as a Biosorbent for Reactive Dyes Removal from Industrial Wastewater

Research Abstract
Propionic acid modified bagasse was used for the removal of reactive yellow 2 and reactive blue 4. The effects of pH, contact time, initial dye concentrations, adsorbent particle size and adsorbent dose on the adsorption of the two dyes were investigated. Additionally, the desorption process and intra-particle diffusion were studied. Acidic pH values were favorable for adsorption of both dyes. The equilibrium adsorption data were best fitted with the Freundlich isotherm for reactive yellow 2 and the Langmiur isotherm for reactive blue 4. The values of their corresponding constants were de-termined. The kinetic for dye adsorption is well described by a pseudo-first order kinetic model for the reactive yellow 2 and by pseudo-second order for the reactive blue 4. The investigation revealed that the hydroxyl groups of bagasse and the carboxylic group of propionic acid play a great role in the removal of both reactive dyes.
Research Authors
Abd El-Aziz A. Said, Aref A. M. Aly, Mohamed M. Abd El-Wahab, Soliman A. Soliman, Aly A. Abd El-Hafez, V. Helmey, Mohamed N. Goda
Research Journal
Journal of Water Resource and Protection
Research Pages
10-17
Research Publisher
SciRes
Research Rank
1
Research Vol
5
Research Year
2013
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