Liver cirrhosis is associated with high morbidity and mortality rates and poses a serious threat to global health due to its rapid progression to cirrhosis and hepatocellular carcinoma. This study aims to assess the anti-fibrotic effect of combination of clove (Syzygium aromaticum) ethanolic extract (CEE) with Silymarin® on carbon tetrachloride (CCl 4)-induced liver fibrosis in an effort to advance their synergistic clinical application as well as their antibacterial and anti-inflammatory activities. Adult rats were divided into six groups (10 animals each) as follows: group (1) included normal rats as control, group (2) included normal rats daily CEE, group (3) comprise of CCl 4-induced liver fibrosis and acts as positive control, group (4) CCl 4-induced liver fibrosis rats those were treated with CEE,(5) CCl 4-induced liver fibrosis rats those were treated with Silymarin® and group (6) CCl₄-induced liver fibrosis rats those were …