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Preparation, insecticidal activity estimation, DFT calculations, and molecular docking of some polyfunctionalized pyridine derivatives

ملخص البحث

This study investigated the insecticidal bioefficacy of seven compounds (1-7) against maize aphid (Rhopalosiphum maidis). Results indicated that LC50 values ranged from 1.52 to 18.45 mg/L for nymphs and 23.96 to 80.73 mg/L for adults. Compound (6) demonstrated the highest potency, with LC50 values of 1.52 mg/L against nymphs and 23.96 mg/L against adults, establishing it as the most effective analogue for potential aphid control. The other compounds also exhibited varying degrees of insecticidal activity. For nymphs, compound (5) was notably effective, followed by compound (7), and compound (3) with LC50 values of 2.23, 2.37, and 2.45 mg/L, respectively, indicating their promising potential. Compounds (4), (2), and (1) showed comparatively lower efficacy against nymphs with LC50 values of 12.19, 14.14, and 18.45 mg/L, respectively. Similarly, for adults of maize aphids, compounds (5), (7), and (3 …

مؤلف البحث
Eman Ali Thabet, Abdullah Abdalkarim Al–Shara, Abdel Haleem M Hussein, Ahmed AK Mohammed, Adel M Kamal El-Dean, Mokhtar A Abdul-Malik, Ali M Drar, Fathia Mohammad Qasem Qaid, Shaban AA Abdel-Raheem
تاريخ البحث
قسم البحث
مجلة البحث
Journal of the Indian Chemical Society
سنة البحث
2025