This study was conducted to evaluate the integrative antioxidant potency of fenugreek seeds suspension powder (FSPS), vitamin E (Vit E), and sodium selenite (Se) against mercuric chloride toxicity (MC) induced oxidative stress in both erythrocytic lysate (EL) and testicular tissue (TT) in Albino male rats. MC was administered orally in drinking water (DW: (50 mg/L= 1/15 of LD50). FSPS (100 g/L soaked for day), Se (2 mg/L) were administered in DW and vit E 150 (mg/100 g diet) mixed in the diet as. The rats were divided into six groups, ten rats each. The first group was control with normal diet and tape water. The second group, consider as positive control, DW containing MC. The third received Vit E (with diet) in addition to MC, the fourth group received MC + Se. The fifth one received MC and FSPS. Finally, the sixth group combination group (COMB group) received DW containing MC, Se in addition to Vit E …