Abstract: A series of new 2-pyrazoline analogues was synthesized. The structures of the synthesized
compounds were elucidated by the analytical and spectroscopic data. Some selected compounds were screened
for the anti-inflammatory activity by using the animal model of carrageenan-induced paw edema in mice.
Additionally, the analgesic and acute toxicity of these compounds were evaluated and exhibited reasonable
results. The anti-oxidant and anti-inflammatory effects of these compounds were established by measuring the
contents of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO), and tumor necrosis factor
alpha (TNF-α) in the edema paw tissue. The results revealed that compounds 5, 6, 7, and 15 could be
recognized as potential multi-potent anti-inflammatory agents.