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A novel fluorescent molecularly imprinted polymer membrane (FMIM) has been developed for the selective binding and qualitative detection of pepsin enzyme, a biomarker indicative of gastroesophageal reflux disease (GERD). This study utilises the high selectivity offered by molecular imprinting techniques to capture pepsin enzyme within complex biological matrices, such as human saliva. Additionally, fluorescent carbon dots integrated into the membrane matrix provide instant visual detection of pepsin. Various combinations of functional monomers and cross-linkers were systematically evaluated to investigate their impact on the binding capacity and mechanical stability of the resultant FMIMs. The optimum performance was achieved with a mixture of two hydrophilic monomers, namely N-(hydroxymethyl)acrylamide and acrylamide, in conjunction with N,N-methylenebis(acrylamide) as the cross-linking agent. The developed FMIM demonstrated a binding capacity of 21.56 mg g-1, surpassing that of the fluorescent non-imprinted membrane (FNIM) at 8.49 mg g-1. Moreover, the binding of FMIM to pepsin was tested against other competitor enzymes to verify its selectivity. Furthermore, comprehensive characterisation of both FMIM and FNIM was conducted using various analytical techniques to ensure their structural integrity and functionality. Ultimately, the developed FMIM exhibited effective binding of pepsin in standard solutions and samples, enabling enrichment and visual detection of the biomarker enzyme
The department announces that the lecture will be held on Tuesday from 2:30 PM to 4:00 PM. The practical session will be conducted in two periods:
The department announces that the lecture will be held on Sunday from 12:00 PM to 4:00 PM. This is to ensure adherence to the schedule
The department announces that the lecture will be held on Thursday from 8:30 AM to 10:30 AM, and the practical session will take place from 8:30 AM to 12:00 PM. This is to ensure adherence to the schedule
The midterm exam for the "Entrepreneurship" course for Fifth-Year Pharm D students will take place on Thursday, March 13, 2025, starting at 12:00 PM in Hall (2) beneath the lecture halls.
By the will of God, the midterm exam for first-year Pharm D students (National University) in the Pharmaceutical Analytical Chemistry – 2 course will be held on Sunday, April 6, 2025, at 2:00 PM in Lecture Halls (A) and (B), as well as in Halls (1) and (2), on the following parts:-
1-Acid-base applications
2- Preciptimetry
By the will of God, the midterm exam for third-year students in the Scientific Writing course will be held on Monday, March 10, 2025, at 9:00 AM in the department's lecture hall and student laboratories.
By the will of God, the midterm exam for Clinical Pharmacy students, Semester (2), in the Pharmaceutical Analytical Chemistry – 2 course will be held on Wednesday, April 9, 2025, during the scheduled practical session on the following parts:
1-Acid-base applications
2- Preciptimetry
