Use of hormonal contraceptives in clinical settings and in the general public, may exacerbate pre-existing anxiety and depressive symptoms. The PLISSIT model is a sex therapy counseling model which can aid any persuasive practitioner to tackle women's sexual health. Aim: Evaluating the Effectiveness of PLISSIT Model on Sexual Dysfunction and Psychological Distress among Women Using Hormonal Contraception. Research design: A quasi experimental research design was used in this study. Research setting: Family Planning and Gynecological Clinics at Woman's Health Hospital, Assiut University. Sample: In this study a purposive sample of 100 women. Tools: three tools were used in this study, (1) women assessment sheet, (2) Female Sexual Function Index tool (FSFI), (3) Depression Anxiety Stress Scales tool (DASS-21). Results: There were highly statistically significant differences between pre and post implementation mean scores of female sexual function among women (p=0.000**) with a significant increase of the total mean score of female sexual function from pre-test (15.09±6.24) to (28.49±5.08) in post-test among women. Conclusion: PLISSIT model had positive effect on sexual dysfunction and psychological distress among Women using hormonal contraception. Recommendations: Nurses should provide counseling through PLISSIT model for women using hormonal contraception to optimize the sexual health and sexual quality for life.

 Keywords: Hormonal Contraception, Psychological Distress, PLISSIT Model, Sexual Dysfunction, Women.