Background: The most significant clinical consequence of liver cirrhosis is ascites, which is the buildup of fluid in the abdominal cavity. Aim: This study was conducted to evaluate the effect of development of nursing education program for patients with Child Pugh score A liver cirrhosis to minimize ascites. Design: A quasi-experimental research design. Sample: A purposive sample of sixty adult patients with child Pugh score A liver cirrhosis, which placed into two equal-numbered groups at random: the study group and the control group. Setting: The tropical medicine department, the gastroenterology department, and the outpatient clinic at El-Rajhi Liver Hospital, Assiut University. Tools: Tool I: A Structured Interview, Tool II: Compliance of patients with medication and Tool III: Assessment occurrence and degree of ascites sheet. Results: The result revealed that regarding study groups, after 6 months (16.7%) developed ascites while after 12 months (33.3%) developed ascites in comparison to control groups which after 6 months were (46.7%) while after 12 months (73.3%) developed ascites. Conclusion: Nursing education has a good effect on improving patients’ knowledge, increasing level of drug compliance and minimizing occurrence of ascites Recommendations: It is recommended to repeat of this research using a bigger likelihood sample picked from other regions so that the results can be used more widely.