Background: Asthma is a chronic respiratory disease characterized by recurrent attacks of breathlessness and wheezing which vary in severity and frequency from person to person. Aimof the study: To evaluate the effect of nursing instructions for asthmatic patients on minimizing local side effects of Inhaled Corticosteroids (ICS). Research design: Quasi experimental (pre – posttest) research design was utilized to conduct this study. Setting: The study was conducted at internal medical unit of Al-Badary Central Hospital, Assiut, Egypt. Sample: 90 males and females adult patients with asthma receiving ICS. Tools of data collection: Tool (I) Patient assessment sheet and Tool (II) Local side effects assessment sheet. Results: Most of  the studied patients, (90.0%) had a poor level of knowledge about asthma. A significant decrease in local side effects of ICs; hoarseness, dysphonia, dry, sore throat, throat clearing, thirst, and dry cough, among the studied patients after implementation nursing  instructions than before (p. < 0. 01). Conclusion: Implementation of the nursing instructions for asthmatic patients had a positive effect on minimizing the many local side effects of ICS as hoarseness, dysphonia, dry, sore throat, throat clearing, thirst, and dry cough. Recommendation: The booklet should be available for nursing team to increase their awareness and to provide patients with sufficient information for decreasing local side effects of ICS.