Several studies have indicated that nurses' knowledge and practices about bed sores prevention and management are inadequate. The present study aimed to provide nurses with a training program that included the needed knowledge and skills about how to identify, prevent and manage bedsores for immobilized patients and to investigate the impact of that training on nurses' knowledge and practices as well as on patients' condition. Quasi-experimental research design was adopted to conduct the study on (31) nurses working in the trawna and Neurology, Intensive Care Units of Assiut University Hospital, in addition to 100 patients admitted to these units. Four tools were used for data collection: pre/post· test questionnaire sheet, observation checklist, Braden scale and patient assessment sheet. A training program was designed to enrich nurses' knowledge and practices about. identification, prevention and management of bed sores. A pretest was carried out for nurses pre program, in addition to post· program testing immediately, one and two months after wards. Moreover, a group of 50 immobilized Patients were assessed for development of bedsores before program implementation and another 50 immobilized patients were assessed after program implementation nurses knowledge and practices mean scores about identification, prevention and management of bedsores were improved singifcationly (P=O.OOI for all items) after Program implementation. The impact of attending the program on Braden scale scores for knowledge and practices was also statistically significant (P=O.OO I' for both). Incidence of bed sores' were' significantly more among immobilized patient's program ; implementation than after ward (P=0.0327) Moreover, the incidence of multiple bed sores were more than before program implementation .(24%)'than after' ward (6%). Continued nursing education for the enrichment of nurses' knowledge and augmenting their practices about identification, prevention and management of bed sores is effective in minimizing bed sores for immobilized patients.