Background:Hyperphosphatemia is common among hemodialysis patients, and independently associated with high mortality risk in those patients. Aim: To examine the effect of sugar free chewing gum as a supplemental approach instructions to control serum phosphorus level among hemodialysis patients. Researchdesign: A quasi-experimental research design. Setting: Kidney Dialysis Unit at Assiut University Hospital, Egypt. Sample:120 patients were randomized in two groups, experimental and control and met the inclusion criteria. Patients in the experimental group were instructed to chew two pieces of gum, for 60 min, during fasting periods in the morning and the afternoon and to use of phosphate binder with meals for 4weeks. Tool: The interview questionnaire sheet involved two parts: Part I: Demographic characteristics for patients: Part II: Clinical data of patients: Results: Serum phosphorus level was significantly lower in the experimental group than in control after 4weeks of using sugar free chewing gum (8.200 ±1.34 to5.30 ±0.94 (p 0.0001). Conclusion: The use of sugar free chewing gum as a supplemental approach instructions was effective in controlling serum phosphorus level. Recommendation: The study was highly reinforced the need for sugar free chewing gum to be used by hemodialysis patients for its positive effect on controlling serum phosphorus level.