Bums are manifestations of injuries that are typically inflicted on the skin and other epithelial tissues. The metabolic disturbance and fluid imbalance are direct results of burn trauma and of fluid losses from the bum wound. Hypermetabolism and hypercatabolism characterize the body's response to a burn injury resulting in increase in energy and protein requirements. This study aimed to determine the effect of two nutritional regimens on wound healing of moderate burned patients. It was carried out at the burns unit of the Assiut university hospital, from October 2002 till December 2004. A sample included lOO adult recent moderately burned patients assigned sequentially into a group I (n=50) who their calculated caloric requirement form natural nutrients including the ordinary hospital diet, and group II (n=50) who received outline hospital diet & supplementation by commercial products rich in protein and carbohydrates (sustagen or Ensure). Monitoring the effect of &0 regimens was done by laboratory investigation. and anthropometric measurements. The main results reveal significant increase in weight gain in group Il compared to group I at discharge. There was an increase in value of mid-arm muscle circumference (MAMC) body mass index (BMI) and triceps skin fold thickness(TSF) on discharge than 011 admission. In addition, a significant relation ship of serum transferrine, albumin and serum protein among patients groups.