Diabetes foot ulcers are common complications of diabetes mellitus; they are the major cause of morbidity, mortality, and disability. The aim of this study is to evaluate the impact of implementing a designed nursing intervention protocol on prevention of diabetic foot complication. Subjects and methods, Design: pre- post test study design was utilized, the study was conducted on 60 male and female patients in diabetic educational center at Assiut University Hospital, three tools were used for data collection. Tool I: interview questionnaire sheet, tool 11: foot assessment sheet, and tool Ill: an observational checklist .Designed nursing intervention protocol was conducted through 4 theoretical and practical sessions and evaluation was done by using the three previous tools every one month till three months after implementation of the protocol of care to assess patients' knowledge and practice about foot care and to assess patients' foot condition. The finding of the study revealed changes and improvement in patients knowledge and practice about foot care which were indicated by significant difference (p0.05) between before and after implementing of nursing intervention protocol. It can be concluded that, most of patients had poor knowledge and performance of foot care while after implementation of a designed intervention protocol, the number and percent of the subjects who had calluses, blisters, dryness, and fissure subside due to improvement of patients' knowledge and practice about good and proper foot care. Recommendations, based on the results of the present study the following are recommended, periodic implementation of a designed nursing intervention protocol about foot care for all diabetic patients in hospital setting, and in out patients setting during follow up visits to provide diabetic patients with the necessary and required knowledge and skills about foot care. Diabetic patients should be encouraged to do daily self examination of feet and to adopt proper foot care practice; this can be helped by providing them with illustrated, colorful and simplified pamphlets.