Gentamicin (GNT) is a potent aminoglycoside antibiotic widely used to treat life-threatening bacterial infections. We aim to investigate the potential protective effect of ursodeoxycholic acid (UDCA) against GNT-induced nephrotoxicity. In this study, 24 male Wistar rats were used and randomly divided into four groups of six animals each. Control group received 0.5% carboxymethyl cellulose orally for 15 days, GNT group received GNT 100 mg/kg/day ip for 8 days, UDCA group received UDCA orally for 15 consecutive days at a dose of 60 mg/kg/day suspended in 0.5% carboxymethyl cellulose and UDCA-pretreated group received UDCA orally for 7 days then co-administered with GNT ip for 8 days at the same fore-mentioned doses. Serum levels of kidney function parameters (urea, creatinine, uric acid and albumin) were measured. Renal tissues were used to evaluate oxidative stress markers; malonaldehyde (MDA

Gentamicin (GNT) is a potent aminoglycoside antibiotic widely used to treat life-threatening bacterial infections. We aim to investigate the potential protective effect of ursodeoxycholic acid (UDCA) against GNT-induced nephrotoxicity. In this study, 24 male Wistar rats were used and randomly divided into four groups of six animals each. Control group received 0.5% carboxymethyl cellulose orally for 15 days, GNT group received GNT 100 mg/kg/day ip for 8 days, UDCA group received UDCA orally for 15 consecutive days at a dose of 60 mg/kg/day suspended in 0.5% carboxymethyl cellulose and UDCA-pretreated group received UDCA orally for 7 days then co-administered with GNT ip for 8 days at the same fore-mentioned doses. Serum levels of kidney function parameters (urea, creatinine, uric acid and albumin) were measured. Renal tissues were used to evaluate oxidative stress markers; malonaldehyde (MDA

Gentamicin (GNT) is a potent aminoglycoside antibiotic widely used to treat life-threatening bacterial infections. We aim to investigate the potential protective effect of ursodeoxycholic acid (UDCA) against GNT-induced nephrotoxicity. In this study, 24 male Wistar rats were used and randomly divided into four groups of six animals each. Control group received 0.5% carboxymethyl cellulose orally for 15 days, GNT group received GNT 100 mg/kg/day ip for 8 days, UDCA group received UDCA orally for 15 consecutive days at a dose of 60 mg/kg/day suspended in 0.5% carboxymethyl cellulose and UDCA-pretreated group received UDCA orally for 7 days then co-administered with GNT ip for 8 days at the same fore-mentioned doses. Serum levels of kidney function parameters (urea, creatinine, uric acid and albumin) were measured. Renal tissues were used to evaluate oxidative stress markers; malonaldehyde (MDA

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Purpose : To study the influence of age, refractive error and axial length on choroidal thickness in normal eyes using swept-source OCT. Setting/Venue: Assiut University and Alforsan eye center, Assiut, Egypt Methods : Choroidal thickness (CT) was measured by a swept-source optical coherence tomography in 97 eyes of 49 normal myopic volunteers. The subjects were classified into groups according to age, the degree of myopia and axial length. Correlation between CT and age, axial length and myopia were done for different groups. Axial length was measured using IOL Master. OCT measurements were performed using Topcon DRI-1 SSOCT. CT was automatically calculated and shown as a colored topographic map with nine subfields defined by the ETDRS-style grid. Results : CT tends to decrease with advance of age. A negative correlation found between the central subfoveal CT and the age (r= -0.329, P= 0.001, R²= 0.108). Although there was no significant correlation between CT and degree of myopia (r= 0.159, P= 0.120, R²= 0.025), CT decreases with increase of myopia except with group > -8 D. CT tends to decrease as the axial length increase. A negative correlation was found between the central subfoveal CT and axial length (r= -0.340, P= 0.001, R²= 0.115) for ETDRS map and (r= -0.202, p= 0.047, R²= 0.041) for central subfoveal line. Conclusions : Axial length and age have a negative correlation with choroidal thickness, while the spherical equivalent of refractive error in myopes doesn’t affect choroidal thickness.