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Spondylodiscitis: Experience of Surgical Management of Complicated Cases After Failed Antibiotic Treatment

Research Abstract
Introduction: The term Spondylodiscitis (SD) involves infection of the vertebra (Spondylitis), infection of the intervertebral disc (Discitis), or both (Spondylodiscitis). SD represents a diagnostic and therapeutic challenge to any spine surgeon. Any delay in its diagnosis or management may cause serious long-term morbidity or even lead to mortality. In this study, we report the experience of our Institution in the management of severe and complicated cases of SD. Methods: Over a period of 1 year, 39 patients with the diagnosis of SD were surgically treated in Assiut University Hospital, Assiut, Egypt. The management processes were tailored according to the clinical condition, radiological and lab studies of each case; and patients were then prospectively followed-up until they were cured (for a minimum of 6 months). The outcomes were analyzed, to be able to give recommendations while aiming to improve the overall outcome of such dangerous health issue. Results: In this series, patients were managed surgically by drainage and debridement of the infection site with/without instrumented fusion. Results included: satisfactory fusion was achieved in 97.3% of patients (confidence interval [CI] = 0.6856-1.3421). Neurological Improvement Rate (NIR) was 71.5% (Statistically significant improvement P-value = 0.014) and reoperation rate was 5% (CI = 0.00621-0.18525). Mortality rate was 7.7% (CI = 0.016-0.209). Several aspects were analyzed in each case. Conclusion: Surgical management of severe and complicated cases of SD allows for effective debridement and rapid cure of inflammation, earlier patient mobilization and significantly shorter duration of antibiotic usage. © The Authors, published by EDP Sciences, 2020.
Research Authors
Kamal A.M., El-Sharkawi M.M., El-Sabrout M., Hassan M.G.
Research Journal
SICOT-J
Research Pages
1-8
Research Publisher
EDP Sciences
Research Rank
1
Research Vol
Volume 6,5
Research Website
https://www.sicot-j.org/articles/sicotj/abs/2020/01/sicotj190086/sicotj190086.html
Research Year
2020

Personal Health of Spine Surgeons Can Impact Perceptions, Decision-Making and Healthcare Delivery During the COVID-19 Pandemic-A Worldwide Study

Research Abstract
Objective: To determine if personal health of spine surgeons worldwide influences percep-tions, healthcare delivery, and decision-making during the coronavirus disease 2019 (CO-VID-19) pandemic. Methods: A cross-sectional study was performed by distributing a multidimensional survey to spine surgeons worldwide. Questions addressed demographics, impacts and perceptions of COVID-19, and the presence of surgeon comorbidities, which included cancer, cardiac disease, diabetes, obesity, hypertension, respiratory illness, renal disease, and current tobacco use. Multivariate analysis was performed to identify specific comorbidities that influenced various impact measures. Results: Across 7 global regions, 36.8% out of 902 respondents reported a comorbidity, of which hypertension (21.9%) and obesity (15.6%) were the most common. Multivariate analysis noted tobacco users were more likely to continue performing elective surgery during the pandemic (odds ratio [OR], 2.62; 95% confidence interval [CI], 1.46–4.72; p = 0.001) and were less likely to utilize telecommunication (OR, 0.51; 95% CI, 0.31–0.86; p = 0.011), whereas those with hypertension were less likely to warn their patients should the surgeon become infected with COVID-19 (OR, 0.57; 95% CI, 0.37–0.91; p = 0.017). Clinicians with multiple comorbidities were more likely to cite personal health as a current stressor (OR, 1.32; 95% CI, 1.07–1.63; p = 0.009) and perceived their hospital’s management un-favorably (OR, 0.74; 95% CI, 0.60–0.91; p = 0.005). Conclusion: This is the first study to have mapped global variations of personal health of spine surgeons, key in the development for future wellness and patient management initia-tives. This study underscored that spine surgeons worldwide are not immune to comorbidi-ties, and their personal health influences various perceptions, healthcare delivery, and de-cision-making during the COVID-19 pandemic. © 2020 by the Korean Spinal Neurosurgery Society.
Research Authors
Sayari A.J., Harada G.K., Louie P.K., McCarthy M.H., Nolte M.T., Mallow G.M., Siyaji Z., Germscheid N., Cheung J.P.Y., Neva M.H., El-Sharkawi M., Valacco M., Sciubba D.M., Chutkan N.B., An H.S., Samartzis D.
Research Journal
Neurospine
Research Pages
313-330
Research Publisher
Korean Spinal Neurosurgery Society
Research Rank
1
Research Vol
17(2)
Research Website
https://www.e-neurospine.org/journal/view.php?doi=10.14245/ns.2040336.168
Research Year
2020

Spine Surgery and COVID-19: The Influence of Practice Type on Preparedness, Response, and Economic Impact

Research Abstract
Study Design: Cross-sectional observational cohort study. Objective: To investigate preparation, response, and economic impact of COVID-19 on private, public, academic, and privademic spine surgeons. Methods: AO Spine COVID-19 and Spine Surgeon Global Impact Survey includes domains on surgeon demographics, location of practice, type of practice, COVID-19 perceptions, institutional preparedness and response, personal and practice impact, and future perceptions. The survey was distributed by AO Spine via email to members (n = 3805). Univariate and multivariate analyses were performed to identify differences between practice settings. Results: A total of 902 surgeons completed the survey. In all, 45.4% of respondents worked in an academic setting, 22.9% in privademics, 16.1% in private practice, and 15.6% in public hospitals. Academic practice setting was independently associated with performing elective and emergent spine surgeries at the time of survey distribution. A majority of surgeons reported a >75% decrease in case volume. Private practice and privademic surgeons reported losing income at a higher rate compared with academic or public surgeons. Practice setting was associated with personal protective equipment availability and economic issues as a source of stress. Conclusions: The current study indicates that practice setting affected both preparedness and response to COVID-19. Surgeons in private and privademic practices reported increased worry about the economic implications of the current crisis compared with surgeons in academic and public hospitals. COVID-19 decreased overall clinical productivity, revenue, and income. Government response to the current pandemic and preparation for future pandemics needs to be adaptable to surgeons in all practice settings. © The Author(s) 2020.
Research Authors
Weiner J.A., Swiatek P.R., Johnson D.J., Louie P.K., Harada G.K., McCarthy M.H., Germscheid N., Cheung J.P.Y., Neva M.H., El-Sharkawi M., Valacco M., Sciubba D.M., Chutkan N.B., An H.S., Samartzis D.
Research Journal
Global Spine Journal
Research Pages
NULL
Research Publisher
SAGE Publications Ltd
Research Rank
1
Research Vol
NULL
Research Website
https://journals.sagepub.com/doi/full/10.1177/2192568220949183
Research Year
2020

Assessment of Interobserver Variability for CT Scan–Based Evaluation of Posterior Ligament Complex Injury in Thoracolumbar Fractures: An International Multicenter Pilot Study

Research Abstract
Study Design: A multicenter, pilot study, for radiological assessment of thoracolumbar spine fractures was performed with the participation of 7 centers in Africa, Europe, Asia, and South America as a part of the AO Foundation network. Objectives: To determine the interobserver variability for computed tomography (CT) scan–based evaluation of posterior ligament complex (PLC) injury in thoracolumbar fractures. Methods: Forty-two observers including 1 principal investigator at each participating center performed variability assessment. Each center contributed toward a total of 91 patient images with A3 or A4 thoracolumbar burst fractures (T11-L2) with or without suspected PLC injury. Pathological fractures, multilevel injuries, obvious posterior bony element injury and translation/dislocation injuries were excluded. Ten patients were randomly selected and commonly reported CT parameters indicating PLC injury, including superior inferior endplate angle, vertebral body height loss, local kyphotic deformity, interspinous distance and interpedicular distance were assessed for variability. Observer values were compared with an experienced gold rater in spinal trauma. Analysis of variability was performed for all observers, between the principal investigators and also between observers participating in each center. Results: The studied parameters showed considerable variability in measurements among all observers and amongst all participating centers. The variability between the principal investigators was lower, but still substantial. The deviation of observer measurements from the gold rater were also significant for all CT parameters. Conclusions: CT-based radiological parameters previously reported to be suggestive of PLC injury showed considerable variability and magnetic resonance imaging verification of a PLC injury in all doubtful cases is suggested. © The Author(s) 2019.
Research Authors
Maheswaran A., Aiyer S.N., Farouk O., El-Sharkawi M., Park J.-B., O’Brien A., Oluwole I., Wang Y., Arruda A.D.O., Rajasekaran S.
Research Journal
Global Spine Journal
Research Member
Research Pages
118-129
Research Publisher
SAGE Publications Ltd
Research Rank
1
Research Vol
Vol 10, Issue 2, 2020
Research Website
https://journals.sagepub.com/doi/full/10.1177/2192568219839414
Research Year
2020

Assessment of Interobserver Variability for CT Scan–Based Evaluation of Posterior Ligament Complex Injury in Thoracolumbar Fractures: An International Multicenter Pilot Study

Research Abstract
Study Design: A multicenter, pilot study, for radiological assessment of thoracolumbar spine fractures was performed with the participation of 7 centers in Africa, Europe, Asia, and South America as a part of the AO Foundation network. Objectives: To determine the interobserver variability for computed tomography (CT) scan–based evaluation of posterior ligament complex (PLC) injury in thoracolumbar fractures. Methods: Forty-two observers including 1 principal investigator at each participating center performed variability assessment. Each center contributed toward a total of 91 patient images with A3 or A4 thoracolumbar burst fractures (T11-L2) with or without suspected PLC injury. Pathological fractures, multilevel injuries, obvious posterior bony element injury and translation/dislocation injuries were excluded. Ten patients were randomly selected and commonly reported CT parameters indicating PLC injury, including superior inferior endplate angle, vertebral body height loss, local kyphotic deformity, interspinous distance and interpedicular distance were assessed for variability. Observer values were compared with an experienced gold rater in spinal trauma. Analysis of variability was performed for all observers, between the principal investigators and also between observers participating in each center. Results: The studied parameters showed considerable variability in measurements among all observers and amongst all participating centers. The variability between the principal investigators was lower, but still substantial. The deviation of observer measurements from the gold rater were also significant for all CT parameters. Conclusions: CT-based radiological parameters previously reported to be suggestive of PLC injury showed considerable variability and magnetic resonance imaging verification of a PLC injury in all doubtful cases is suggested. © The Author(s) 2019.
Research Authors
Maheswaran A., Aiyer S.N., Farouk O., El-Sharkawi M., Park J.-B., O’Brien A., Oluwole I., Wang Y., Arruda A.D.O., Rajasekaran S.
Research Journal
Global Spine Journal
Research Pages
118-129
Research Publisher
SAGE Publications Ltd
Research Rank
1
Research Vol
Vol 10, Issue 2, 2020
Research Website
https://journals.sagepub.com/doi/full/10.1177/2192568219839414
Research Year
2020

The Impact of COVID-19 Pandemic on Spine Surgeons Worldwide

Research Abstract
Study Design: Cross-sectional, international survey. Objectives: The current study addressed the multi-dimensional impact of COVID-19 upon healthcare professionals, particularly spine surgeons, worldwide. Secondly, it aimed to identify geographical variations and similarities. Methods: A multi-dimensional survey was distributed to surgeons worldwide. Questions were categorized into domains: demographics, COVID-19 observations, preparedness, personal impact, patient care, and future perceptions. Results: 902 spine surgeons representing 7 global regions completed the survey. 36.8% reported co-morbidities. Of those that underwent viral testing, 15.8% tested positive for COVID-19, and testing likelihood was region-dependent; however, 7.2% would not disclose their infection to their patients. Family health concerns were greatest stressor globally (76.0%), with anxiety levels moderately high. Loss of income, clinical practice and current surgical management were region-dependent, whereby 50.4% indicated personal-protective-equipment were not adequate. 82.3% envisioned a change in their clinical practice as a result of COVID-19. More than 33% of clinical practice was via telemedicine. Research output and teaching/training impact was similar globally. 96.9% were interested in online medical education. 94.7% expressed a need for formal, international guidelines to manage COVID-19 patients. Conclusions: In this first, international study to assess the impact of COVID-19 on surgeons worldwide, we identified overall/regional variations and infection rate. The study raises awareness of the needs and challenges of surgeons that will serve as the foundation to establish interventions and guidelines to face future public health crises. © The Author(s) 2020.
Research Authors
Louie P.K., Harada G.K., McCarthy M.H., Germscheid N., Cheung J.P.Y., Neva M.H., El-Sharkawi M., Valacco M., Sciubba D.M., Chutken N.B., An H.S., Samartzis D.
Research Journal
Global Spine Journal
Research Pages
534-552
Research Publisher
SAGE Publications Ltd
Research Rank
1
Research Vol
Vol 10, Issue 5, 2020
Research Website
https://journals.sagepub.com/doi/full/10.1177/2192568220925783
Research Year
2020

Learning from the Past: Did Experience with Previous Epidemics Help Mitigate the Impact of COVID-19 Among Spine Surgeons Worldwide?

Research Abstract
Purpose: Spine surgeons around the world have been universally impacted by COVID-19. The current study addressed whether prior experience with disease epidemics among the spine surgeon community had an impact on preparedness and response toward COVID-19. Methods: A 73-item survey was distributed to spine surgeons worldwide via AO Spine. Questions focused on: demographics, COVID-19 preparedness, response, and impact. Respondents with and without prior epidemic experience (e.g., SARS, H1NI, MERS) were assessed on preparedness and response via univariate and multivariate modeling. Results of the survey were compared against the Global Health Security Index. Results: Totally, 902 surgeons from 7 global regions completed the survey. 24.2% of respondents had prior experience with global health crises. Only 49.6% reported adequate access to personal protective equipment. There were no differences in preparedness reported by respondents with prior epidemic exposure. Government and hospital responses were fairly consistent around the world. Prior epidemic experience did not impact the presence of preparedness guidelines. There were subtle differences in sources of stress, coping strategies, performance of elective surgeries, and impact on income driven by prior epidemic exposure. 94.7% expressed a need for formal, international guidelines to help mitigate the impact of the current and future pandemics. Conclusions: This is the first study to note that prior experience with infectious disease crises did not appear to help spine surgeons prepare for the current COVID-19 pandemic. Based on survey results, the GHSI was not an effective measure of COVID-19 preparedness. Formal international guidelines for crisis preparedness are needed to mitigate future pandemics. © 2020, The Author(s).
Research Authors
Weiner J.A., Swiatek P.R., Johnson D.J., Louie P.K., Harada G.K., McCarthy M.H., Germscheid N., Cheung J.P.Y., Neva M.H., El-Sharkawi M., Valacco M., Sciubba D.M., Chutken N.B., An H.S., Samartzis D.
Research Journal
European Spine Journal
Research Pages
1789-1805
Research Publisher
Springer
Research Rank
1
Research Vol
Issue 8-Volume 29
Research Website
https://link.springer.com/article/10.1007%2Fs00586-020-06477-6
Research Year
2020

Vaginal misoprostol before elective cesarean section for preventing neonatal respiratory distress: a randomized controlled trial

Research Abstract
NULL
Research Authors
Ahmed M. Makhlouf, MD,1 Abo Bakr A. Mitwaly, MD,1 Ahmed Nasr, MD,1 Esraa Badran, MD,1 Samuel H. Ilya, MSc,1 Ahmed M. Abbas, MD1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Egypt
Research Journal
POG in Press, November 2019, Article 1 [12 p.].
Research Pages
NULL
Research Publisher
NULL
Research Rank
2
Research Vol
NULL
Research Website
NULL
Research Year
2019

Vaginal misoprostol before elective cesarean section for preventing neonatal respiratory distress: a randomized controlled trial

Research Abstract
NULL
Research Authors
Ahmed M. Makhlouf, MD,1 Abo Bakr A. Mitwaly, MD,1 Ahmed Nasr, MD,1 Esraa Badran, MD,1 Samuel H. Ilya, MSc,1 Ahmed M. Abbas, MD1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Egypt
Research Journal
POG in Press, November 2019, Article 1 [12 p.].
Research Member
Research Pages
NULL
Research Publisher
NULL
Research Rank
2
Research Vol
NULL
Research Website
NULL
Research Year
2019

Vaginal misoprostol before elective cesarean section for preventing neonatal respiratory distress: a randomized controlled trial

Research Abstract
NULL
Research Authors
Ahmed M. Makhlouf, MD,1 Abo Bakr A. Mitwaly, MD,1 Ahmed Nasr, MD,1 Esraa Badran, MD,1 Samuel H. Ilya, MSc,1 Ahmed M. Abbas, MD1
1Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, Egypt
Research Journal
POG in Press, November 2019, Article 1 [12 p.].
Research Member
Research Pages
NULL
Research Publisher
NULL
Research Rank
2
Research Vol
NULL
Research Website
NULL
Research Year
2019
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