Abstract

This study evaluates the nephroprotective effect of a copper (II)-albumin complex against bromobenzene (BB)-induced renal toxicity in male rats. BB (300 mg/kg twice weekly for 4 weeks) induced significant nephrotoxicity, evidenced by elevated serum creatinine (p< 0.01) and urea (p<0.001) versus controls. Histopathology revealed tubular necrosis and fibrosis. Co-treatment with the copper-albumin complex (400 mg/kg) reversed creatinine (p<0.05) and UA (p<0.05), demonstrating partial but significant recovery. This is the first report highlighting albumin’s dual role in enhancing copper bioavailability and renal protection. Animals (n=15/group) were divided into control, BB-only, and BB + copper-albumin groups. Serum biomarkers (urea, creatinine, and uric acid) and blinded histopathology (H&E, Sirius Red) were analyzed. The copper-albumin dose was selected based on prior efficacy studies without hepatotoxicity. Results confirm the complex’s therapeutic potential against BB-induced injury, likely via antioxidant mechanisms. The study aligns BB’s dosing with subacute toxicity models, emphasizing industrial relevance without overstating human exposure risks. In conclusion, the copper-albumin complex mitigates BB nephrotoxicity, underscoring its promise as a therapeutic agent. Further research is needed to elucidate molecular pathways and validate findings across sexes.

Background and objectives

Platelet indices are widely available and relatively cheap platelet parameters. The critical objective of this study is to assess the reliability of platelet indices as biomarkers for diagnosis and prognosis in adult thrombocytopenic patients.

Methods

A retrospective case–control study, including 81 immune thrombocytopenia (ITP) cases, 50 aplastic anemia (AA) cases, and 150 participants as a control group. This study included patients admitted from 2016 to 2021 to the Clinical Hematology Unit, Department of Internal Medicine, University Hospital. The collected data included sociodemographic information, clinical data, laboratory data, and an assessment of the therapeutic response in the studied groups.

Results

For the diagnosis of adult thrombocytopenic patients, platelet distribution width (PDW) showed the best diagnostic accuracy (85% for ITP and 91.9% for AA) at cutoff points of 14.9% and 17.2%, respectively. This was followed by mean platelet volume (MPV) with diagnostic accuracies of 77% for ITP and 89.3% for AA at a cutoff point of 9.4 fl. Platelet large cell ratio (PLCR) demonstrated insignificant accuracy in diagnosing either ITP or AA.

Conclusion

Platelet indices can play a crucial influence in the diagnosis, not the prognosis, of adult thrombocytopenia.

Trial registration

NCT05116033. https://classic.clinicaltrials.gov/ct2/show/NCT05116033

Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.

Methods

The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was …

A laparoscopic appendectomy (LA) was performed mostly on uncomplicated appendicitis due to opinions about its safety when it was first introduced. Nevertheless, there are still concerns about surgical difficulties in managing complicated appendicitis with laparoscopy, possible post-op complications and conversion to an open appendectomy (OA) during the surgery.

Methods

The study consists of 30 patients who underwent laparoscopic appendectomy in department of General Surgery at Assiut University hospitals. The study population was enrolled after fulfilling the selection criteria from department of General Surgery. Informed consent was taken from all the patients who are involved in this study. Patients diagnosis was based on clinical findings, complete blood counts, and abdominal sonography.

Results

Thirty patients underwent laparoscopic appendectomy for complicated appendicitis. Of the 30 patients, perforated appendix cases are 27, gangrenous appendix are 1, appendicular abscess only one case. Post operation wound infection, conversion rate and hospital stay rate very less.

Conclusions

The present study proved that laparoscopic appendectomy is the best approach in complicated appendicitis.