Validation of an IGF-CTP scoring system for assessing hepatic reserve in egyptian patients with hepatocellular carcinoma

Research Abstract
Background The Child-Turcotte-Pugh score (CTP) is the standard tool for hepatic reserve assessment in hepatocellular carcinoma (HCC). Recently, we reported that integrating plasma insulin-like growth factor-1 (IGF-1) level into the CTP score was associated with better patient risk stratification in two U.S. independent cohorts. Our current study aimed to validate the IGF-CTP score in patients who have different demographics and risk factors. Patients and Methods We prospectively recruited 100 Egyptian patients and calculated their IGF-CTP score compared to CTP score. C-index was used to compare the prognostic significance of the two scoring systems. Finally, we compared our results with our U.S. cohorts published data. Results IGF-CTP score showed significant better patient stratification compared to CTP score in the international validation cohort. Among CTP class A patients, who usually considered for active treatment and clinical trial enrollment, 32.5% were reclassified as IGF-CTP class B with significantly shorter OS than patients reclassified as class A with hazard ratio [HR] = 6.15, 95% confidence interval [CI] = 2.18 -17.37. Conclusion IGF-CTP score showed significantly better patient stratification and survival prediction not only in the U.S. population but also in international validation population, who had different demographics and HCC risk factors.
Research Authors
Samir Shehata, Manal M. Hassan, Lianchun Xiao, Ju-Seog Lee, Sheree Cheung, Hoda H. Essa, Hesham M. Hassabo, Ahmed S. Shalaby, Eman Mosad, Kanwal Raghav, Asif Rashid, Robert A. Wolff, Jeffrey S. Morris, Hesham M. Amin and Ahmed O. Kaseb
Research Department
Department of Rheumatology ,Rehabilitation & physical medicine
Research File
26111.doc (0 bytes)
26111.pdf (60.95 KB)
NULL (0 bytes)
Research Journal
Oncotarget
Research Pages
-21193-21207
Research Publisher
NULL
Research Rank
1
Research Vol
Vol 6 - NO 25
Research Website
NULL
Research Year
2015

COMPARISON OF PATIENT-CONTROLLED EPIDURAL ANALGESIA WITH PATIENT-CONTROLLED INTRAVENOUS ANALGESIA USING TRAMADOL

Research Abstract
NULL
Research Authors
HAMDY ABASS YOUSEF
ESSAM EZZAT ABDELHAKEEM
ALAA ELDEEN MAHMOUD KHEDRE
Research Department
Department of  Anesthesia and Intensive Care
Research File
26001.doc (0 bytes)
26001.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
EGYPTIAN JOURNAL OF INTENSIVE CARE
Research Pages
535-550
Research Publisher
NULL
Research Rank
2
Research Vol
VOL 6 No 1
Research Website
NULL
Research Year
2001

Extracellular enzymes and toxins produced by fungi isolated from human corneal infections.

Research Abstract
NULL
Research Authors
Ashraf K. Al-Hussaini, Ahmed M. Moharram, Mohamed I. Abdel-Kader, Saeed M. AlGhalibi.
Research Department
Department of Ophthalmology
Research File
25949.doc (0 bytes)
25949.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Presented at the 34th annual Annual Meeting of the Ocular Microbiology and Immunology Group, Dallas, Texas USA,2000 . Published in The Egyptian Journal of Cataract and Refractives Surgery vol 6 No.1 2000 5-14
Research Pages
NULL
Research Publisher
Egyptian Journal of Cataract and Refractives Surgery vol 6 No.1 2000 5-14
Research Rank
3
Research Vol
Egyptian Journal of Cataract and Refractives Surgery vol 6 No.1 2000 5-14
Research Website
NULL
Research Year
2000

The Spectrum of Bacterial and Fungal Keratitis in Southern Egypt

Research Abstract
NULL
Research Authors
Ashraf K. Al-Hussaini, Saeed M. AlGhalibi, Mohamed I. Abdel-Kader, Ahmed M. Moharram.
Research Department
Department of Ophthalmology
Research File
25948.doc (0 bytes)
25948.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Presented as Poster at the annual meeting of the Americal Academy of Ophthalmology in Dallas, Texas, USA, October, 22-25, 2000. Abstract on page 206 of the final program.
Research Pages
5-9
Research Publisher
Cataract & Cornea –Volume 8 - February 2002, 5-9
Research Rank
2
Research Vol
Volume 8 - February 2002, 5-9
Research Website
NULL
Research Year
2002

Extracellular enzymes and toxins produced by fungi isolated from human corneal infections. Presented at the 34th annual Annual Meeting of the Ocular Microbiology and Immunology Group, Dallas, Texas USA,2000 .

Research Abstract
NULL
Research Authors
Ashraf K. Al-Hussaini, Ahmed M. Moharram, Mohamed I. Abdel-Kader, Saeed M. AlGhalibi.
Research Department
Department of Ophthalmology
Research File
25947.doc (0 bytes)
25947.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Presented at the 34th annual Annual Meeting of the Ocular Microbiology and Immunology Group, Dallas, Texas USA,2000

Published in:
Egyptian Journal of Cataract and Refractives Surgery
Research Pages
vol 6 No.1 2000 5-14
Research Publisher
NULL
Research Rank
3
Research Vol
vol 6 No.1 2000 5-14
Research Website
NULL
Research Year
2000

Bacterial and fungal endophthalmitis in Upper Egypt: related species and risk factors. . 2012 Aug;

Research Abstract
NULL
Research Authors
Gharamah A, Moharram A, Ismail M, Al-Hussaini A.
Research Department
Department of Ophthalmology
Research File
25940.doc (0 bytes)
25940.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Asian Pac J Trop Biomed
Research Pages
NULL
Research Publisher
Asian Pac J Trop Biomed
Research Rank
1
Research Vol
2(8):655-9. doi: 10.1016/S2221-1691(12)60115-4.
Research Website
NULL
Research Year
2012

Bacterial and fungal endophthalmitis in Upper Egypt: related species and risk factors. . 2012 Aug;

Research Abstract
NULL
Research Authors
Gharamah A, Moharram A, Ismail M, Al-Hussaini A.
Research Department
Department of Ophthalmology
Research File
25940.doc (0 bytes)
25940.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Asian Pac J Trop Biomed
Research Pages
NULL
Research Publisher
Asian Pac J Trop Biomed
Research Rank
1
Research Vol
2(8):655-9. doi: 10.1016/S2221-1691(12)60115-4.
Research Website
NULL
Research Year
2012


Bacterial and fungal keratitis in Upper Egypt: in vitro screening of enzymes, toxins and antifungal activity.
Indian J Ophthalmol.

Research Abstract
NULL
Research Authors
Gharamah AA, Moharram AM, Ismail MA, Al-Hussaini AK.
Research Department
Department of Ophthalmology
Research File
25938.doc (0 bytes)
25938.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Indian J Ophthalmol
Research Pages
196-203.
Research Publisher
Indian J Ophthalmol
Research Rank
1
Research Vol
;62(2):196-203. doi: 10.4103/0301-4738.116463
Research Website
NULL
Research Year
2014


Bacterial and fungal keratitis in Upper Egypt: in vitro screening of enzymes, toxins and antifungal activity.
Indian J Ophthalmol.

Research Abstract
NULL
Research Authors
Gharamah AA, Moharram AM, Ismail MA, Al-Hussaini AK.
Research Department
Department of Ophthalmology
Research File
25938.doc (0 bytes)
25938.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Indian J Ophthalmol
Research Pages
196-203.
Research Publisher
Indian J Ophthalmol
Research Rank
1
Research Vol
;62(2):196-203. doi: 10.4103/0301-4738.116463
Research Website
NULL
Research Year
2014

some Endocrinal Changes in Children with
Beta Thalassemia Major

Research Abstract
NULL
Research Authors
Zeinab M.mohey El-Deen
Ahlam M.Ismail
Monam.Abdel Meguid
mohamet.Hard
Research Department
Department of Pediatrics
Research File
25914.doc (0 bytes)
25914.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Accpted for publication in Egyption Journal of Haematology .Volime 39 NO.2,April2014
Research Pages
NULL
Research Publisher
NULL
Research Rank
2
Research Vol
NULL
Research Website
NULL
Research Year
2014
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