SPECT/CT Improves Inter-Observer Agreement of Equivocal
Osseous Lesions Detected on Planar Bone Scan

Research Abstract
Aim To compare inter-reader agreement for planar and SPECT/CT interpretation of equivocal osseous lesions detected on bone scintigraphy in cancer patients. Materials & Methods This prospective study recruited patients known to have primary tumor referred for bone scintigraphy with their planar images showing solitary or few equivocal osseous lesions. Every patient underwent planar whole body scan followed by SPECT/CT for the concerned region(s). The gold standard was based on clinical/ imaging follow-up for at least 6-12 months. Two experienced readers (reader 1 has 8-year experience&reader 2 has 12-year experience) scored each lesion on a subjective 5-point score for the possibility of being malignant (1=benign, 2= probably benign, 3 = equivocal, 4=probably malignant & 5 = malignant). True & false results were identified were identified in relation to the gold standard. Kappa measure of agreement was measured for both modalities. Results A total of 150 patients were included in this study (110 females ,40 males) with median age 54 years (range:7-84). On planar imaging, both readers successfully identified 48 true positive (TP) & 19 true negative (TN) patients. Both readers were false positive (FP) in 31&false negative (FN) in 3 patients. They disagree in 2 patients. Moderate agreement was noted (kappa = 0.55). While on SPECT/CT imaging, both readers successfully identified 58 TP & 62 TN patients. Both readers reported FP results in 11 & FN in 2 patients. They disagree in a total of 9 patients. Perfect agreement was noted (kappa = 0.82). Conclusion SPECT/CT significantly improved inter-observer agreement among readers for equivocal osseous lesions detected on planar bone scintigraphy.
Research Authors
Y. G. A. Abdelhafez1, N. Bashank2, L. Eloteify2, M. Mekkawy2;
Research Department
Department of Rheumatology ,Rehabilitation & physical medicine
Research File
32261.doc (2.96 KB)
32261.pdf (60.98 KB)
NULL (0 bytes)
Research Journal
Eur J Nucl Med Mol Imaging (2016) 43 (Suppl 1):S1–S734
Research Pages
492
Research Publisher
springer
Research Rank
1
Research Vol
43(suppl 1)
Research Website
NULL
Research Year
2016

B-Cell-attracting Chemokine CXCL13 as a marker of disease activity in systemic lupus erythematosus(SLE)

Research Abstract
A correlation was detected between the chemokine CXC ligand 13(CXCL13) and lupus nephritis, but there is no data recorded in literature about a relationship with other disease manifestations in systemic lupus erythematosus (SLE). Therefore, we sought to investigate the relationship between CXCL13 and overall disease activity and other disease manifestations in SLE.
Research Authors
Eman Ahmed Hamed , Eman H El-Hakeim , Marwa A A Galal ,Eman mosad , Nada Mahmoud Mostfa Nasr
Research File
30063.doc (0 bytes)
30063.pdf (60.12 KB)
NULL (0 bytes)
Research Journal
Aktuelle Rheumatologie
Research Pages
1-6
Research Publisher
Thieme
Research Rank
1
Research Vol
42
Research Website
https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-121875
Research Year
2017

Novel Therapeutic Strategies to Target Protein Quality Control Compartments in Multiple Myeloma

Research Abstract
NULL
Research Authors
Mohamed AY Abdel Malek, Sajjeev Jagannathan, Ehsan Malek, Nikhil Vad, Douaa M Sayed, Sahar A Elgammal, Hanan G Abd El-Azeem, Nabila M Thabet, James J Driscoll
Research Department
Department of Clinical Pathology
Research File
26747.doc (0 bytes)
26747.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Blood
Research Pages
NULL
Research Publisher
NULL
Research Rank
1
Research Vol
NULL
Research Website
NULL
Research Year
2014

Chronic eosinophilic leukemia transformation into acute myeloid leukemia with monocytic differentiation

Research Abstract
NULL
Research Authors
Mohamed AY Abdel Malek, Douaa M Sayed, Youseryeia A Ahmad, James J Driscoll
Research Department
Department of Clinical Pathology
Research File
26744.doc (0 bytes)
26744.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Case Reports in Internal Medicine
Research Pages
NULL
Research Publisher
NULL
Research Rank
1
Research Vol
NULL
Research Website
NULL
Research Year
2014

Rare Extraperitoneal Involvement with Fatal Outcome in a Case of Bilateral Luteinized Thecoma of the Ovaries with Sclerosing Peritonitis

Research Abstract
NULL
Research Authors
Mohamed A Medhat, Mohamed AY Abdel Malek, Saad Zaki, Ahmed Helmy, James J Driscoll
Research Department
Department of Clinical Pathology
Research File
26743.doc (0 bytes)
26743.pdf (0 bytes)
NULL (0 bytes)
Research Journal
Case reports in oncological medicine
Research Pages
NULL
Research Publisher
NULL
Research Rank
1
Research Vol
NULL
Research Website
NULL
Research Year
2014

Molecular chaperone GRP78 enhances aggresome delivery to autophagosomes to promote drug resistance in multiple myeloma

Research Abstract
NULL
Research Authors
Mohamed AY Abdel Malek, Sajjeev Jagannathan, Ehsan Malek, Douaa M Sayed, Sahar A Elgammal, Hanan G Abd El-Azeem, Nabila M Thabet, James J Driscoll
Research Department
Department of Clinical Pathology
Research File
26740.doc (0 bytes)
26740.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Oncotarget
Research Pages
NULL
Research Publisher
NULL
Research Rank
1
Research Vol
NULL
Research Website
NULL
Research Year
2015

Two or More Levels Anterior Cervical Discectomy and Fusion (ACDF) Using Stand-Alone PEEK Cages Filled With Bone Graft Substitute

Research Abstract
NULL
Research Authors
Mohamad El-Meshtawy, Belal Elnady, Khaled Hassan, Hamdan Ahmad, Mohamad Hassan, Mahmoud Fouad, Amr Abo El-Fadl
Research Department
Department of Orthopedic Surgery and Traumatology
Research File
26668.doc (0 bytes)
26668.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
Egyptian spine journal
Research Pages
Pages 30-37
Research Publisher
NULL
Research Rank
2
Research Vol
Volume 6
Research Website
NULL
Research Year
2013

Posterior only surgical correction of severe adolescent idiopathic scoliosis > 70o using high density pedicle screws

Research Abstract
NULL
Research Authors
Belal Elnady,Mohammad El-Sharkawi,Mohamed El-Meshtawy,Faisal F Adam,Khaled M Hassan
Research Department
Department of Orthopedic Surgery and Traumatology
Research File
26667.doc (0 bytes)
26667.pdf (0 bytes)
uploaded_full_txt (0 bytes)
Research Journal
International Journal of Multidisciplinary Research and Development
Research Pages
Pages 114-117
Research Publisher
NULL
Research Rank
1
Research Vol
Volume 2 Issue 11
Research Website
http://www.allsubjectjournal.com/
Research Year
2015
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