Introduction: Oral corticosteroids form the cornerstone for management of most children with nephrotic syndrome. Prednisolone should be administered at a dose of 60 mg/m²/day (maximum daily dose, 80 mg) for 4-6 weeks. Daily therapy may be either given, as a single morning or divided doses. We aim by this study to compare the regimen of giving steroids in a single daily dose with that of giving them in three-divided doses, as regard the compliance, response to treatment, and occurrence of complications. Patients and methods: The study was conducted on 30 patients having presumed steroid-responsive minimal change nephrotic syndrome. 15 patients were given prednisolone in a single daily dose. The other 15 patients were given prednisolone in three divided doses. Results: There was no significant statistical differences between the two groups of patients as regard the duration of treatment before remession or complications of nephrotic syndrome. No complications related to steroids were observed in any of our patients. Conclusion: Prednisolone, as a single morning dose is as effective as divided doses for inducing remission with no higher risk of complications. As single-dose steroid therapy is likely to be associated with better drug compliance, we recommend it as the regimen of choice for treatment of nephrotic syndrome.

NULL

NULL

NULL

NULL

Abstract: Background: There is an interesting growing evidence for a relation between bronchiolitis and vitamin D. This suggests a possible benefit from Vitamin D therapy to children with bronchiolitis. Methods: We performed a double-blind, randomized clinical trial on 89 infants with bronchiolitis. Patients were randomized to receive vitamin D or placebo. Results: The intervention group, which received vitamin D therapy, had significant improvement in 3 parameters: The mean time taken for resolution of the disease, the mean time taken for the improvement of oral feeding and the duration of hospitalization. All these outcomes in the intervention group (vitamin D) were significantly better than the control (placebo) group with p 0.001, 0.05 and 0.01 respectively. Our study supported the efficacy of vitamin D therapy in bronchiolitis. Conclusion: This double-blinded, randomized placebo controlled trial of vitamin D supplementation 100 IU/kg daily in Egyptian children with bronchiolitis found a clinically and statistically significant reduction in hospitalization with rapid recovery of the disease. Our study suggested that short term supplementation with Vitamin D given daily during the course of illness, starting from day one, may help in resolution of bronchiolitis.

Abstract: Background: There is an interesting growing evidence for a relation between bronchiolitis and vitamin D. This suggests a possible benefit from Vitamin D therapy to children with bronchiolitis. Methods: We performed a double-blind, randomized clinical trial on 89 infants with bronchiolitis. Patients were randomized to receive vitamin D or placebo. Results: The intervention group, which received vitamin D therapy, had significant improvement in 3 parameters: The mean time taken for resolution of the disease, the mean time taken for the improvement of oral feeding and the duration of hospitalization. All these outcomes in the intervention group (vitamin D) were significantly better than the control (placebo) group with p 0.001, 0.05 and 0.01 respectively. Our study supported the efficacy of vitamin D therapy in bronchiolitis. Conclusion: This double-blinded, randomized placebo controlled trial of vitamin D supplementation 100 IU/kg daily in Egyptian children with bronchiolitis found a clinically and statistically significant reduction in hospitalization with rapid recovery of the disease. Our study suggested that short term supplementation with Vitamin D given daily during the course of illness, starting from day one, may help in resolution of bronchiolitis.

Abstract: Background: There is an interesting growing evidence for a relation between bronchiolitis and vitamin D. This suggests a possible benefit from Vitamin D therapy to children with bronchiolitis. Methods: We performed a double-blind, randomized clinical trial on 89 infants with bronchiolitis. Patients were randomized to receive vitamin D or placebo. Results: The intervention group, which received vitamin D therapy, had significant improvement in 3 parameters: The mean time taken for resolution of the disease, the mean time taken for the improvement of oral feeding and the duration of hospitalization. All these outcomes in the intervention group (vitamin D) were significantly better than the control (placebo) group with p 0.001, 0.05 and 0.01 respectively. Our study supported the efficacy of vitamin D therapy in bronchiolitis. Conclusion: This double-blinded, randomized placebo controlled trial of vitamin D supplementation 100 IU/kg daily in Egyptian children with bronchiolitis found a clinically and statistically significant reduction in hospitalization with rapid recovery of the disease. Our study suggested that short term supplementation with Vitamin D given daily during the course of illness, starting from day one, may help in resolution of bronchiolitis.

Abstract: Background: There is an interesting growing evidence for a relation between bronchiolitis and vitamin D. This suggests a possible benefit from Vitamin D therapy to children with bronchiolitis. Methods: We performed a double-blind, randomized clinical trial on 89 infants with bronchiolitis. Patients were randomized to receive vitamin D or placebo. Results: The intervention group, which received vitamin D therapy, had significant improvement in 3 parameters: The mean time taken for resolution of the disease, the mean time taken for the improvement of oral feeding and the duration of hospitalization. All these outcomes in the intervention group (vitamin D) were significantly better than the control (placebo) group with p 0.001, 0.05 and 0.01 respectively. Our study supported the efficacy of vitamin D therapy in bronchiolitis. Conclusion: This double-blinded, randomized placebo controlled trial of vitamin D supplementation 100 IU/kg daily in Egyptian children with bronchiolitis found a clinically and statistically significant reduction in hospitalization with rapid recovery of the disease. Our study suggested that short term supplementation with Vitamin D given daily during the course of illness, starting from day one, may help in resolution of bronchiolitis.

Abstract: Background: There is an interesting growing evidence for a relation between bronchiolitis and vitamin D. This suggests a possible benefit from Vitamin D therapy to children with bronchiolitis. Methods: We performed a double-blind, randomized clinical trial on 89 infants with bronchiolitis. Patients were randomized to receive vitamin D or placebo. Results: The intervention group, which received vitamin D therapy, had significant improvement in 3 parameters: The mean time taken for resolution of the disease, the mean time taken for the improvement of oral feeding and the duration of hospitalization. All these outcomes in the intervention group (vitamin D) were significantly better than the control (placebo) group with p 0.001, 0.05 and 0.01 respectively. Our study supported the efficacy of vitamin D therapy in bronchiolitis. Conclusion: This double-blinded, randomized placebo controlled trial of vitamin D supplementation 100 IU/kg daily in Egyptian children with bronchiolitis found a clinically and statistically significant reduction in hospitalization with rapid recovery of the disease. Our study suggested that short term supplementation with Vitamin D given daily during the course of illness, starting from day one, may help in resolution of bronchiolitis.