Currently, the whole world is facing energy shortage and water crisis. Management of water and energy usage in irrigation is essential to overcome the current crisis. This research introduces a techno-economic study to achieve simultaneous optimization of cost, active power loss and water quantity without violating the crop water requirement. Four scenarios are proposed incorporating energy demand-side management, PV panels integration and modification of the irrigation schedule and irrigation methodology for comparison against the existing scenario of pump-based irrigation system in Karot line, Assiut, Egypt. The grid-connected PV panels scenario achieves minimum system cost as well as minimum total system active-power loss and water quantity when compared with the other scenarios. Grid-connected PV panels with surface irrigation reduce the total system cost by 93% when compared with that of the Karot line. On the other hand, grid-connected PV panels with drip irrigation give a much more saving in water quantity and a further reduction in the total system active-power loss by 48.1 and 25.13%, respectively, when compared with those of the Karot line case.