One of the most prevalent metabolic conditions affecting women in their reproductive years causing infertility or subfertility is Polycystic Ovary Syndrome (PCOS). This pilot study aimed to assess whether Glycyrrhiza glabra L. aqueous extract (GAE) could prevent or treat PCOS in the rats which received Estradiol®. Following acclimation, the adult female Wistar albino rats weighing 160-200 grams were randomly assigned to four groups. Normal rats were used in the first group as the controls. In the second group, normal rats were administered 100 mg/kg of Glycyrrhiza glabra L orally for six weeks. In the third group, PCOS animal models that were not treated were served as the positive control. Finally, Glycyrrhiza glabra L was administered for six weeks to a group of PCOS animal models. The obtained results demonstrated that the PCOS caused by Estradiol® was significantly restored by Glycyrrhiza glabra L extracts …