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New burn model for developing consistent second- and third-degree burn injuries in rats

Research Abstract

Burns appeared deeper with more distinct borders in groups (B) and (C) than in group (A). The stainless-steel rod at 100 ºC created burn injuries of the second degree, evidenced by the sloughing of the epidermis and necrosis in the epithelium and upper part of the dermis. Heating at 150 and 200 ºC created third-degree burn injuries, where necrosis involved the epidermis and dermis and extended to the subcutaneous fat and muscles. The depth of the burn wound in the group (B) (371.2 ± 41.3 μm) and (C) (385.2 ± 38.0 μm) was significantly deeper compared with the group (A) (178 ± 46.6 μm) (P < 0.001). The digital drying oven is a reliable, reproducible, and controllable heating device for creating burn models. The stainless-steel rod (63 g and 8 mm) heated at 100 and 150 ºC with a contact time of 30 s is adequate for creating consistent second and third-degree burn injuries in rats, respectively.

Research Authors
Ahmed Ibrahim, Khaled MA Hassanein, Mahmoud Soliman, Abdelnaby M Elshahawy
Research Date
Research Department
Research Journal
BMC Research Notes
Research Pages
179
Research Publisher
SPRINGER NATURE
Research Rank
International Q2
Research Vol
18
Research Website
https://doi.org/10.1186/s13104-025-07200-8
Research Year
2025