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Effect of diabetes control or growth hormone and somatomedin-C levels in young subjects with insulin-dependent diabetes mellitus

Research Abstract

serum levels of GH, Somatomedin-C as well as linear body growth were determined in 28 young diabetic subjects (14 children and 14 preadolescents) and in 20 normal age-matched control. All children and 50% of the preadolescent patients were poorly controlled. The mean hight in both groups was insignificantly lower than that in controls. Serum GH was higher in both groups while SM-C was insignificantly lower in children and insignificantly higher in preadolescents than that in the controls. An inverse correlation between GPP and SM-C in the poorly controlled preadolescent diabetics. These finding may suggest that the decreased linear growth results in poorly controlled diabetics from decreased serum SM-C. Meanwhile, the elevated GH levels may imply a state of GH resistance and may help to explain the inadequate diabetes control among this group patients.

Research Authors
Al-Sawi N.M
Sobh M.A
Ghazally M.H
Hossam El-Din M Omar
Research Department
Research Journal
Arab.J.Lab.Med.
Research Member
Research Pages
8997
Research Publisher
Cairo University Press
Research Rank
2
Research Vol
20 (1)
Research Year
1994