The growing demand for clean energy has intensified research into sustainable hydrogen production methods. This study explores a potentially less hazardous catalytic approach for hydrogen generation through sodium borohydride (NaBH₄) hydrolysis, utilizing a copper-aspartate metal-organic framework (Cu-Asp MOF) as a green and efficient catalyst. It was heat-treated at 500 °C for 1 h to produce CuO NPs. The synthesized Cu-Asp MOF and CuO NPs were characterized using XRD, FTIR, EDX, XPS and SEM to confirm their structural and morphological properties. The catalytic performance of Cu-Asp MOF and CuO NPs was evaluated under varying conditions, including temperature, NaBH₄ concentration, and catalyst loading, demonstrating high hydrogen production rates with excellent recyclability while utilizing Cu-Asp MOF. Kinetics analysis revealed a low activation energy of 42.7 kJ/mol, indicating the MOF's superior catalytic activity. The Cu-Asp MOF catalyzes the reaction ∼3.5 times faster than CuO NPs under the same experimental conditions. Thermodynamic results indicated the spontaneous and entropy driven nature for the catalytic reaction. Furthermore, the use of a biocompatible ligand (aspartate) enhances the environmental sustainability of the process. This work presents a promising, cost-effective, and green alternative to conventional noble metal-based catalysts, contributing to the advancement of clean hydrogen energy technologies.