In this manuscript, we study heat generation effects on Magnetohydrodynamic mixed convection in hybrid nanofluid (Tio2-Cu/Water) in a wavy porous cavity with a lid-driven using Local Thermal Non Equilibrium (LTNE) condition. The impacts of the inclined magnetic field, internal heat generation, and the volume of the solid fraction on the flow and heat structures are investigated. The dominant equations and the conditions of the boundaries are converted for dimensionless equations. This equation is solved numerically using the SIMPLER algorithm based on the finite volume method. The results are represented graphically by streamlines, isotherms, iso-concentrations, local Nusselt numbers, local Sherwood numbers, and average Nusselt numbers. The results showed that the isothermal wavy walls and the internal heat source had an essential effect on the fluid flow and heat transfer. Furthermore, the position of the heat source and large values of the heat generation parameter enhanced the rate of heat transfer and decreased the local Nusselt and Sherwood numbers. On the other hand, the rise of the Hartmann number restricted nanofluid transport. Moreover, the presence of a porous medium reduced the nanofluid velocity while enhancing the heat transport in the cavity.