Background: Hands are the most common burn injury sites. Appropriate range of motion exercise is essential to ensure good hand functional recovery. Aim: to evaluate effect of physical rehabilitation program based on range of motion exercise on hand joints function among patients with thermal burn Research design: A quasi - experimental (pre / post assessment) design. Setting: the study was conducted in Burn Department, Intermediate Care Room and Burn Outpatient Clinic at the Main Assuit University Hospital. Sample: A purposeful sample of (30) patients, their ages ranged from (20 - 65) years. Tools: tool (1): Patients structured interview questionnaire. Tool (2): Hand Burn Severity assessment scale. Tool (3): Hand contracture severity rating scale. Results: More than half of the patients were males and married (56.7% & 53.3%), (80%) of them had flame thermal burn& (50%) represented by 2nd degree burn with zone A (TBSA). There was a statistical significance difference as regard patients range of motion of mean score of different hand joints mostly in flexion between pre & post (3&6 weeks after program implementation (p < 0.005). Conclusion: significant improvement in hand joints range of motion function among patients with thermal burn post physical rehabilitation program application. Recommendation: using new physical rehabilitation modalities as Smart Glove that can be operated only through active ROM movement for patients with burn hand