Background: Diabetes mellitus constantly changes a patient’s life. Patient’s self care, consisting of daily insulin injections or oral anti-diabetic agents, self monitoring of blood glucose and diabetic diet has an impact on QOL. The aim of the present study was to assess quality of life for patients with type II diabetes mellitus, to develop and implement an educational nursing program for patients with type II diabetes mellitus, to evaluate the effect of applying the educational nursing program on quality of life for patients with type II diabetes mellitus pre and after two months from application of educational program. Methods: The study was conducted in the internal medicine department, internal medicine and diabetes clinic at University Hospital (Assiut–Egypt). Sixty adult patients were divided randomly equally into two groups (study group and control group) thirty for each group. The following tools were utilized for data collection: first tool “Structured patient interview questionnaire sheet”; it included two parts (socio-demographic characteristic and medical data), second tool “World Health Organization Quality of life (WHOQOL-WHO) scale”.