ackground: One of the most common reasons for hospitalization, morbidity, and mortality related to digestive illnesses is Non-variceal upper GIT bleeding. Despite the improvement in the field, management of patients with Non- variceal Upper Gastrointestinal Bleeding (NVUGIB) has become more challenging due to comorbidities and complex therapies. This study aimed to evaluate the effect of implementing nursing care protocol on clinical outcomes of non variceal upper gastrointestinal bleeding patients. Design: A quasi-experimental research design was used. Setting: Gastroenterology Intensive care unit at Sohag University hospital, Upper Egypt. Sample: A convenient sample of 80 adult (male and female) patients was included. Tools: Three tools were utilized to collect data, Too - NVUGIB assessment sheet, Tool II: Nursing NVUGIB care protocol and Tool III: Clinical outcome evaluation tool. Results: Illustrate that most common cause of non-variceal upper GIT bleeding in studied patients was peptic ulcer followed by Gastritis, 50% of study& 45% of control group were using NSAID before coming to hospital. In relation to mortality risk using Rockall score on 1st day of admission about half of study and control group were at high risk for mortality, while at 3rd day 52.5% in study group were at low risk. Conclusion: the implementation of nursing protocol for patients with NVUGIB improves patients' clinical outcomes and decrease rate ofcomplication occurrence. Recommendations: Provide Gastroenterology intensive care unit with clear, illustrative nursing care protocols and booklets for management of patient with Non-variceal upper GIT bleeding. Keywords: Non-variceal upper GIT bleeding, Nursing protocol and clinical outcomes