Background: The future foresight used (VUCA leadership) in organizations to becoming more professional and widespread, support strategic management & increase the innovation capacity. Aim: Explore the effect of VUCA leadership educational program on nurse manager's readiness for change. Design: A quasi-experimental design. Setting: It conducted at Assiut University Hospitals Subjects: Quota sample was used which includes nurse managers have job experience 10 years and more. Methods: Included, personal characteristics for the studied subject, VUCA leadership questionnaire & change readiness scale as regarded assessment phase and Program implementation & evaluation sheet which consisted of outcome of the program & Effectiveness of the program through used a structured questionnaire, Results: The highest percentages of nurse managers have low knowledge about VUCA leadership in preprogram assessment, but high knowledge in immediate post and follow up phase. Conclusion: There were improvements the nurse manager's knowledge immediately after implementation of the educational program and this improvement was mostly retained after three months (follow up) with a slight decline from immediate post program implementation. Recommendation: The top Managers should continue to use (VUCA leadership) as to strategic future foresight at Assiut University Hospitals to encourage changes for all care givers at these Hospitals.