Background and objective: A febrile (fever) convulsion is a fit or seizure that occurs in children with fever. The key responsibilities of the nurse are to protect the child from injury during seizure and assist in the treatment of the underlying cause. The objective of this study is to determine the impact of educational program on nurses’ knowledge and performance. Methods: Design: Quasi-experimental research design. Subjects and methods: 44 nurses who working at Assiut Children Hospital. Tools: A structured interview sheet and observational check list. Results: Statistically significant difference between nurses’ knowledge and practices after post-test and follow-up. Conclusions: The nurses’ knowledge regarding care of child with febrile seizure were not enough with some unsafe practices. The study recommended On Job Training (OJT) programs are suggested in order to refresh and update nurses’ knowledge.