The present study aimed to explore the relationship between nurse's absenteeism and incidences of medication errors and bed sores among patients at El Manya University Hospital. The study was conducted at six inpatient units at El Manya University Hospital. The study sample included all staff nurses who were working at these units, and all patients admitted during period of data collection (3 months).Retrospective auditing was done for nurses absenteeism rate and patient observation checklist was used for monitoring incidences of medication errors and bed sores. The findings of this study revealed that the medication error rate was high in general medicine unit (56.17) and the bed sores rate was high in CCU (7.36) .On the other hand, it was found that the absenteeism rate was high among nurses in obstetric and general medicine units (1.82,1.50) respectively. It was concluded from the study finding that there was a highly significant positive correlation between nurses' absenteeism rate and incidence of both medication errors and bed sores. It was recommended to make supervision for nurses performance especially in drug administration ,also training programs were crushly needed with emphasis on preventive measures against bed sores ,in addition to adopt risk management system in the hospital.