Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal discomfort or pain, accompanied by alterations in bowel habits. Its exact pathophysiology remains unclear, but mental health problems are recognized as a major risk factor. Therefore, this study aimed to identify the prevalence of IBS among medical students and explore its association with various factors, including comorbid mental health issues.

This multicentric cross-sectional study employed an online self-administered questionnaire, distributed among medical students from 27 faculties of medicine across seven countries in the Middle East and North Africa. Universities were selected using a simple random sampling technique. Possible associates were evaluated using the Generalized Anxiety Disorder Questionnaire, the Patient Health Questionnaire, and the Rome IV Diagnostic …