Sjӧgren's syndrome (SS) is a systemic autoimmune disease affecting mainly the exocrine glands. Tubulointerstitial nephritis (TIN) is the most predominant renal involvement with lymphocyte and plasma cells
infiltration of the interstitium. We report a case of young female with SS presented with renal tubular acidosis (RTA), polyradiculoneuropathy &proteinuria. Renal biopsy revealed granulomatous interstitial nephritis. Granuloma formation is rarely seen in cases of SS.