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Discussion of the doctoral thesis submitted by the doctor - Wael Farhat Ali Hafez
Trimetazedine with hyperinsulinimea–euoglycemia, N‐acetyl cysteine, and vitamin C: A new approach concept for management of aluminum phosphide poisoning
Research Abstract
Aluminum phosphide (AlP) is commonly used as a powerful suicidal tool. The exact mechanism of acute toxicity has not been well defined despite high mortality rates as well as its supportive treatment including rapid decontamination and institution of resuscitative measures. The current study aimed to investigate a new combination therapy using trimetazidine, N-acetyl cysteine, vitamin C, and hyperinsulinemia–euglycemia to manage acute AlP poisoning. Acute AlP-induced cardiotoxicity, hemodynamic changes, and hepatotoxicity were evaluated using electrocardiogram, creatinine kinase MB iso-enzyme, troponin-1, blood pressure, random blood glucose level, liver function tests, and histopathological changes in both the heart and liver in a rabbit model of AlP poisoning. The results showed that the new regimen therapy ameliorates the toxic effect of AlP with significant improvement in survival, cardiovascular and hemodynamic parameters in addition to histopathological changes. These results highlight the strong cardioprotective, antioxidant, hepatoprotective effects of the new combined therapy along with correction of hemodynamic changes and hyperglycemia as a potential target in the management of acute AlP poisoning.
Research Date
Research Department
Research Journal
Journal of Biochemical and Molecular Toxicology
Research Member
Research Pages
e22931
Research Rank
1
Research Vol
36 (1)
Research Year
2022
The activities of the DNA lab course for forensic medicine and diagnosis
تحت رعاية
ا. د/طارق الجمال رئيس الجامعه
ا. د/ علاء عطيه عميد الكلية ورئيس مجلس إدارة المستشفيات الجامعية
ا.د/سعد زكي وكيل الكلية لشئون البيئة وخدمة المجتمع
ورئاسة
ا. د/ رنده حسين رئيس قسم الطب الشرعي والسموم الاكلينيكية
ا.د/هاله فتحي مدير معمل الحمض النووي
ا. د/ هبه عطيه يسي. مقرر الدورة
انتهاء فعاليات دورة معمل الحمض النووي للطب
الشرعي و التشخيص بنجاح
والتي تم عقدها في الفتره من ٢٧ إلي ٢٨ يوليو ٢٠٢٢
حضر الدورة التدريبية أطباء من كلية طب المنيا وكلية الطب باسوان
ودارت حول أهمية فحص الحمض النووي وكيفية استخلاصه وتحليله ومطابقته بقضايا الطب الشرعي
