Objectives To assess the value of DWI with its two components (DWI-b1000 and DWI b0) images in assessment of active MS and in defining dissemination in time (DIT) and dissemination in space (DIS) in those patients. Methods Brain MRI studies were performed using T1WI, T2WI, FLAIR and DWI and CE T1WI. Results Twenty-one patients (Males/Females= 6/15) of age range 18–50 years were included. Forty lesions were hyperintense on DWI-b1000 that had significant link to enhancement seen on contrast- enhanced T1WI (100%) indicating disease activity. Using the 2010 revised McDonald criteria: In 9 patients (42.85%), there were [Asymptomatic active lesions (n= 17)]. Those lesions were simultaneously present along with [Non-active demyelinating lesions]; DIT could be diagnosed in these cases based alone on MRI findings. In 12 patients (57.14%) …