Immune thrombocytopenia (ITP) is an acquired autoimmune disease. This study’s objective was to estimate the variations in the population of CD4⁺CD25^+High FoxP3⁺ cells (CD4⁺ regulatory T-lymphocytes; Tregs) in previously untreated children with chronic ITP managed in Assiut University Hospitals, as well as to evaluate the efficacy of high-dose dexamethasone (HD-DXM) in these patients.

Methods

In this study, we investigated the frequencies of T-lymphocyte subsets in 27 untreated children with chronic ITP.

Results

Prior to treatment, the percentages of CD4⁺CD25^High cells and Tregs were significantly lower in the chronic ITP group compared to the control group (p = 0.018 and p < 0.0001, respectively). After treatment with HD-DXM, Tregs and platelets were significantly increased in these patients (p < 0.0001 for both).

Conclusions

Our results suggest that Tregs are deficient in children with